Results 61 to 70 of about 4,881,863 (349)
A Systematic Mapping Study of Empirical Studies performed with Collections of Software Projects [PDF]
, 2021 Juan Andrés Carruthers +2 more
openalex +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
CREATIVITY RISK IN SOFTWARE PROJECTS
Research on Enterprise in Modern Economy Theory and Practice, 2018 Creativity risk appears when the goals related to creativity are not achieved or unwanted consequences of using creativity methods take place. This paper deals with creativity risk using dimensions of directed creativity and risk management categories ...
Anna Bobkowska
doaj +1 more source
Search Heuristics, Case-Based Reasoning and Software Project Effort Prediction [PDF]
, 2002 This paper reports on the use of search techniques to help optimise a case-based reasoning (CBR) system for predicting software project effort. A major problem, common to ML techniques in general, has been dealing with large numbers of case features ...
Hart, J, Kirsopp, C, Shepperd, M J
core +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Software-Engineering Process Simulation (SEPS) model [PDF]
, 1992 The Software Engineering Process Simulation (SEPS) model is described which was developed at JPL. SEPS is a dynamic simulation model of the software project development process.
Abdel-Hamid, T. +2 more
core +1 more source
Improving Software Reliability Forecasting [PDF]
, 1996 This work investigates some methods for software reliability forecasting. A supermodel is presented as a suited tool for prediction of reliability in software project development.
Albeanu, Grigore +4 more
core +3 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source