Results 81 to 90 of about 4,881,863 (349)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

A New Optimized Hybrid Model Based On COCOMO to Increase the Accuracy of Software Cost Estimation [PDF]

Journal of Advances in Computer Engineering and Technology, 2018
The literature review shows software development projects often neither meet time deadlines, nor run within the allocated budgets. One common reason can be the inaccurate cost estimation process, although several approaches have been proposed in this ...
Ramin Saljoughinejad, Vahid Khatibi
doaj  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Le contrôle de la forme des réseaux par leurs membres : le fil de discussion comme réseau d’interaction

Sociologies, 2015
This article investigates the coordination modes on electronic mailing lists showing that a thread can be identified as a replies network extending from the dynamics of the interaction process.
Alexandre Delanoë, Bernard Conein
doaj  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Large Language Models for Early-Stage Software Project Estimation: A Systematic Mapping Study

Applied Sciences
Accurate estimation of software project characteristics during the early stages of development remains a constant challenge in software projects.
Łukasz Radliński, Jakub Swacha
doaj   +1 more source

Integrating Sensor-Network Research and Development into a Software Engineering Curriculum [PDF]

, 2006
The emergence of a sensor-networked world produces a clear and urgent need for well-planned, safe and secure software engineering. It is the role of universities to prepare graduates with the knowledge and experience to enter the work-force with a clear
Bestavros, Azer, Kfoury, Assaf J., Ocean, Michael J.   +2 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

The Astropy Problem [PDF]

, 2016
The Astropy Project (http://astropy.org) is, in its own words, "a community effort to develop a single core package for Astronomy in Python and foster interoperability between Python astronomy packages." For five years this project has been managed ...
Alexander, Michael, Allen, Alice, Ashley, Richard, Asmus, Daniel, Azzollini, Ruyman, Bannister, Michele, Beaton, Rachael, Benson, Andrew, Berriman, G. Bruce, Bilicki, Maciej, Boyce, Peter, Bridge, Joanna, Cami, Jan, Cangi, Eryn, Chen, Xian, Christiny, Nicholas, Clark, Christopher, Collins, Michelle, Comparat, Johan, Cook, Neil, Croton, Darren, Davids, Isak Delberth, Depagne, Éric, Donor, John, Douglas, Stephanie, Du, Alan, Durbin, Meredith, Erb, Dawn, Faes, Daniel, Fernández-Trincado, J. G., Foley, Anthony, Fotopoulou, Sotiria, Frimann, Søren, Frinchaboy, Peter, Garcia-Dias, Rafael, Gawryszczak, Artur, George, Elizabeth, Gonzalez, Sebastian, Gordon, Karl, Gorgone, Nicholas, Gosmeyer, Catherine, Grasha, Katie, Greenfield, Perry, Grellmann, Rebekka, Guillochon, James, Gurwell, Mark, Haas, Marcel, Hagen, Alex, Haggard, Daryl, Haines, Tim, Hall, Patrick, Hellwing, Wojciech, Herenz, Edmund Christian, Hinton, Samuel, Hlozek, Renee, Hoffman, John, Holman, Derek, Holwerda, Benne Willem, Horton, Anthony, Hummels, Cameron, Jacobs, Daniel, Jensen, Jens Juel, Jones, David, Karick, Arna, Kelley, Luke, Kenworthy, Matthew, Kitchener, Ben, Klaes, Dominik, Kohn, Saul, Konorski, Piotr, Krawczyk, Coleman, Kuehn, Kyler, Kuutma, Teet, Lam, Michael T., Lane, Richard, Liske, Jochen, Lopez-Camara, Diego, Mack, Katherine, Mangham, Sam, Mao, Qingqing, Marsh, David J. E., Mateu, Cecilia, Maurin, Loïc, McCormac, James, Momcheva, Ivelina, Monteiro, Hektor, Mueller, Michael, Muna, Demitri, Munoz, Roberto, Naidu, Rohan, Nelson, Nicholas, Nitschelm, Christian, North, Chris, Nunez-Iglesias, Juan, Ogaz, Sara, Owen, Russell, Parejko, John, Patrício, Vera, Pepper, Joshua, Perrin, Marshall, Pickering, Timothy, Piscionere, Jennifer, Pogge, Richard, Poleski, Radek, Pourtsidou, Alkistis, Price-Whelan, Adrian M., Rawls, Meredith L., Read, Shaun, Rees, Glen, Rein, Hanno, Rice, Thomas, Riemer-Sørensen, Signe, Rusomarov, Naum, Sanchez, Sebastian F., Santander-García, Miguel, Santos, Leonardo A. dos, Sarid, Gal, Schoenell, William, Scholz, Aleks, Schuhmann, Robert L., Schuster, William, Scicluna, Peter, Seidel, Marja, Shao, Lijing, Sharma, Pranav, Shulevski, Aleksandar, Shupe, David, Sifón, Cristóbal, Simmons, Brooke, Sinha, Manodeep, Skillen, Ian, Soergel, Bjoern, Spriggs, Thomas, Srinivasan, Sundar, Stevens, Abigail, Streicher, Ole, Suchyta, Eric, Tan, Joshua, Telford, O. Grace, Thomas, Romain, Tonini, Chiara, Tremblay, Grant, Tuttle, Sarah, Urrutia, Tanya, Vaughan, Sam, Verdugo, Miguel, Wagner, Alexander, Walawender, Josh, Wetzel, Andrew, Willett, Kyle, Williams, Peter K. G., Yang, Guang, Zhu, Guangtun, Zonca, Andrea   +153 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source