Results 41 to 50 of about 341,504 (262)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Project risk management in Iranian software projects [PDF]
Journal of Engineering Management and Competitiveness, 2018 Many Software development organizations suffer chronic problems of cost overruns, schedule slips and projects that do not meet the originally specified functions in almost all software projects.
Afshari Ali Reza +2 more
doaj
Cooperation in the development of free software projects
Revista Ingenio, 2014 This article presents a set of elements for cooperation pertinent to free software projects and cooperation theories, based on recognizing how geographically distributed developers in the world find the motivation to create a community around free ...
Byron Cuesta Quintero +1 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Barriers Faced by Women in Software Development Projects
Information, 2019 Computer science is a predominantly male field of study. Women face barriers while trying to insert themselves in the study of computer science. Those barriers extend to when women are exposed to the professional area of computer science. Despite decades
Edna Dias Canedo +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Model to Selecting contractors in Software projects [PDF]
Journal of Information Technology Management, 2011 Organizations in private and public sector assign many projects in information technology (particularly software) field to contractors for implementation every year.
Amir Hassan Nasseri, Amir Afsar
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Risk factors affecting software projects in South Africa
South African Journal of Business Management, 2006 This paper reports on an analysis of risk factors relevant to South African software projects. Seven of the most widely cited studies in the research literature regarding software project risk were evaluated along with a detailed examination of the 53 ...
D. Smith +3 more
doaj +1 more source