Results 61 to 70 of about 4,867,597 (292)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Project risk management in Iranian software projects [PDF]

Journal of Engineering Management and Competitiveness, 2018
Many Software development organizations suffer chronic problems of cost overruns, schedule slips and projects that do not meet the originally specified functions in almost all software projects.
Afshari Ali Reza, Brtka Vladimir, Ćoćkalo-Hronjec Melita   +2 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

value-based multiple software projects scheduling with genetic algorithm

, 2009
Chinese Acad Sci, ISCAS Lab Internet Software TechnologiesScheduling human resources to multiple projects under various resource requirements, constraints and value objectives is a key problem that many software organizations struggle with.
Yang Qiusong, Xiao Junchao, Wang Qing, Liu Dapeng, Li Mingshu, Xie Lizi   +5 more
core   +1 more source

Evaluation of Investment Projects by Computer Software [PDF]

Bartın Orman Fakültesi Dergisi, 2005
Preparing investment projects is a hard & time-consuming process. Not only preparing but also evaluating the investment projects has a lot importance.Hence, a software program evaluating the investment projects has been developed.
Alper AYTEKİN
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Developing a Requirements Model for Software Projects

Ibn Al-Haitham Journal for Pure and Applied Sciences
Requirements elicitation is recognized as one of the most critical activities in the software development process as it has an impact on its success. Studies such as the CHAOS Report, a study based on The [Standish Group]'s CHAOS Research Project on IT ...
Ali Yahya Gheni, Haifaa Jassim Muhasin Muhasin, Hiba Adil Yousif, Yusmdi Yah Jusoh   +3 more
doaj   +1 more source

Risk factors affecting software projects in South Africa

South African Journal of Business Management, 2006
This paper reports on an analysis of risk factors relevant to South African software projects. Seven of the most widely cited studies in the research literature regarding software project risk were evaluated along with a detailed examination of the 53 ...
D. Smith, M. Eastcroft, N. Mahmood, H. Rode   +3 more
doaj   +1 more source