Results 41 to 50 of about 428,429 (314)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Automating Open Source Software License Information Generation in Software Projects [PDF]

Journal of Systemics, Cybernetics and Informatics, 2018
This publication deals with Open Source Software (OSS) compliance. In a previous publication [1], we presented an organizational-technical concept for ensuring basic OSS compliance. Based on this concept, we now address further aspects that are essential
Sergius Dyck, Daniel Haferkorn, Christian Kerth, André Schoebel   +3 more
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An estimate of necessary effort in the development of software projects [PDF]

, 2004
International Workshop on Intelligent Technologies for Software Engineering (WITSE'04). 19th IEEE International Conference on Automated Software Engineering (Linz, Austria, September 20th - 25th, 2004)The estimated of the effort in the development of ...
Rodríguez, Martín, Galván, Inés M., Hernández, Julio, Isasi, Pedro, Galván León, Inés María, Isasi Viñuela, Pedro   +5 more
core  

Onboarding in Open Source Software Projects: A Preliminary Analysis

, 2013
Nowadays, many software projects are partially or completely open-source based. There is an increasing need for companies to participate in open-source software (OSS) projects, e.g., in order to benefit from open source ecosystems. OSS projects introduce
Johnson, Patrik, Fagerholm, Fabian, Borenstein, Jay, Patrik Johnson, Fabian Fagerholm, Alejandro Sanchez Guinea, Jurgen Munch, Jay Borenstein, Münch, Jürgen, Sanchez Guinea, Alejandro   +9 more
core   +1 more source

Exploiting Open-source Projects to Study Software Design

Informatics in Education, 2007
This article presents an approach to using open-source tools and open-source projects to add realistic and practical examples to a course on software design in a professional master's program of software engineering. Students are encouraged to use object-
Christopher P. FUHRMAN
doaj   +1 more source