Results 111 to 120 of about 3,019,176 (294)

Randomized Clinical Study of Laser-Assisted Delivery of Exosome Boosters for Postoperative Facial Scars and Facial Rejuvenation

Life
Postoperative facial scars frequently remain aesthetically problematic despite advances in laser-based treatments, as residual inflammation and disorganized dermal remodeling often limit clinical outcomes. Exosome-based formulations have gained attention
Jei Youn Park, Jun Ho Park
doaj   +1 more source

A Software Rejuvenation Framework for Distributed Computing [PDF]

, 2009
A performability-oriented conceptual framework for software rejuvenation has been constructed as a means of increasing levels of reliability and performance in distributed stateful computing.
Chau, Savio
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Towards optimal software rejuvenation in wireless sensor networks using self-regenerative components

, 2008
The existing researchers on security for sensor networks have mostly concerned about only reconfiguration or only rejuvenation or both mechanisms for adaptation of sensor networks. In this paper we employ self-regenerative software components in order to
Dong Seong Kim, Parvin, Sazia, Kim, Dong Seong, Jong Sou Park, Park, Jong Sou, Sazia Parvin   +5 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The Effect of Extract of Internal Layer of Quercus(Oak)Fruit in Contraction of Vaginal Muscles in Women with Vaginal Relaxation

Journal of Medicinal Plants, 2016
Background: The Quercus (oak) fruit and especially the internal layer of the fruit (jaft) is rich in tannin and due to its astringent effects on the smooth muscles.
N Lorzadeh, F Sepavand, M Solimaninezhad, N Kazemirad   +3 more
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Open and Closed-Loop Predictive Control Strategies for Software Rejuvenation

Software rejuvenation is a cyberdefense mechanism that periodically resets the control software of a system to limit the impact of cyberattacks. We propose open and closed-loop tree-based model predictive controllers to explicitly account for the ...
Camacho, Eduardo F., Maestre, José M., Arauz, T., Chanfreut Palacio, Paula; id_orcid, Quevedo, Daniel E., Chanfreut, P., Camacho, E. F., Quevedo, D. E., Maestre, J. M., https://orcid.org/   +9 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source