Results 101 to 110 of about 3,019,176 (294)

Epigenetic program of ontogenesis and hyperfunction theory: reinterpreting the mechanisms of aging

Frontiers in Aging
This paper presents a comparative analysis of the relationship between aging, the epigenetic program of ontogenesis, and the main postulates of the hyperfunction theory.
Lev Salnikov
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Analysis of software cost models with rejuvenation

, 2000
Software rejuvenation is a preventive maintenance technique that has been extensively studied in the recent literature. In this paper, we extend the classical result by Huang, Kintala, Kolettis and Fulton (1995), and in addition propose a modified ...
Tadashi Dohi
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Investigating the influence of urban green spaces on urban heat island mitigation – taking four districts in Shijiazhuang as an example

Journal of Environmental Engineering and Landscape Management
The primary objective of this scholarly investigation is to elucidate the intricate interplay between the urban heat island (UHI) effect and municipal green spaces.
Nan Zhang, Qiuning Ding, Haitao Wang
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Patient's self-evaluation of two education programs for age-related skin changes in the face: a prospective, randomized, controlled study

Clinical, Cosmetic and Investigational Dermatology, 2011
Linda M Williams1, Jane E Alderman2, Garry Cussell3, John Goldston4, Neal Hamilton5, Adrian C Lim6, Greg J Goodman7, Michael B Halstead8, John D Rogers81Artisan Rejuvenation Clinic, Fortitude Valley, Queensland; 2The Clinic for Essential Beauty, Adelaide,
Williams LM, Alderman JE, Cussell G, Goldston J, Hamilton N, Lim AC, Goodman GJ, Halstead MB, Rogers JD   +8 more
doaj  

Achieving availability and survivability in Wireless Sensor Networks by software rejuvenation

, 2008
Recent works in Wireless Sensor Networks (WSNs) have focused on the survivability. However, there has been no prior work to assess the survivability in systematic way.
Dong Seong Kim, Sang Min Lee, Parvin, Sazia, Kim, Dong Seong, Jong Sou Park, Park, Jong Sou, Lee, Sang Min, Sazia Parvin   +7 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source