Results 81 to 90 of about 3,019,176 (294)

A Comprehensive Model of Android Software Aging and Rejuvenation Considering Battery Saving

, 2023
The more complex the software system, the greater the number of possible combinations of defects that can cause errors, resulting in software defects that are difficult to isolate and expensive to correct in the development stage. An essential feature of
Vitaliy Yakovyna, Natalya Shakhovska, Bohdan Uhrynovskyi   +2 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Inhibition Effect of Prior Injection Rejuvenation Liquid on Initiation of Electrical Tree and Propagation of Tree in Cables

工程科学与技术, 2017
:In order to investigate the inhibition effect of prior rejuvenation on the initiation of electrical tree and the propagation of the tree in the cross-linked polyethylene cable under combined AC voltage and switching overvoltage,the prior rejuvenation ...
周凯, 谢敏, 何珉, 黄明, 侯振奇, 赵世林   +5 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Systematic Review of Image Segmentation Programs in Craniomaxillofacial Surgery

Al-Khawarizmi Engineering Journal
Image segmentation has a significant role in the virtual planning, execution, and evaluation of craniomaxillofacial (CMF) surgical procedures. This systematic review aims to evaluate and compare the image segmentation programs frequently used in the ...
Khawla Rasheed, Auns Al-Neami, Haider Abbas   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Software Rejuvenation in Web Services

International Journal of Computer Applications, 2012
In this paper, we describe the formatting guidelines for IJCA Journal Submission. Software Aging is a phenomenon in which the state of a software system degrades with time and eventually results in software failures. The main causes of software aging are depletion of system resources, data corruption, numerical error accumulation etc.
Anirban Basu, Chaitra S.R.
openaire   +1 more source

Young Women’s Leisure Practices in Yazd: Negotiating Gendered Constraints and Urban Limitations [PDF]

Strategic Research on Social Problems
IntroductionIn contemporary society, leisure is increasingly acknowledged as a fundamental right essential for mental rejuvenation, creativity, and individual growth.
Homa Yousefi, Maliheh Alimondegari, Fariba Seddighi   +2 more
doaj   +1 more source