Results 91 to 100 of about 738 (240)

Rejuvenation and Networking Motivates Librarians to Attend Conferences. A Review of: Vega, Robert D. and Ruth S. Connell. “Librarians’ Attitudes Toward Conferences: A Study.” College & Research Libraries 68.6 (2007): 503‐15.

Evidence Based Library and Information Practice, 2009
Objectives – To determine why professional librarians attend or do not attend conferences and to consider their attitudes toward the various conference offerings and whether conference attendance is important to their careers.Design – An electronic mail ...
Yvonne Hultman Özek
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Facially Driven Dynamic Navigation Guided Implant Surgery For Terminal Dentition

International Dental Journal
Introduction: Facial scan and 3D smile design play a crucial role in guiding implant-supported full-arch rehabilitation, ensuring optimal facial esthetics and functional outcomes. This approach facilitates face rejuvenation by restoring facial asthetics,
Hanqi Gao
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Epigenetic program of ontogenesis and hyperfunction theory: reinterpreting the mechanisms of aging

Frontiers in Aging
This paper presents a comparative analysis of the relationship between aging, the epigenetic program of ontogenesis, and the main postulates of the hyperfunction theory.
Lev Salnikov
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USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Investigating the influence of urban green spaces on urban heat island mitigation – taking four districts in Shijiazhuang as an example

Journal of Environmental Engineering and Landscape Management
The primary objective of this scholarly investigation is to elucidate the intricate interplay between the urban heat island (UHI) effect and municipal green spaces.
Nan Zhang, Qiuning Ding, Haitao Wang
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Patient's self-evaluation of two education programs for age-related skin changes in the face: a prospective, randomized, controlled study

Clinical, Cosmetic and Investigational Dermatology, 2011
Linda M Williams1, Jane E Alderman2, Garry Cussell3, John Goldston4, Neal Hamilton5, Adrian C Lim6, Greg J Goodman7, Michael B Halstead8, John D Rogers81Artisan Rejuvenation Clinic, Fortitude Valley, Queensland; 2The Clinic for Essential Beauty, Adelaide,
Williams LM, Alderman JE, Cussell G, Goldston J, Hamilton N, Lim AC, Goodman GJ, Halstead MB, Rogers JD   +8 more
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