Results 51 to 60 of about 498,159 (256)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

An Open-Source Software Reliability Model Considering Learning Factors and Stochastically Introduced Faults

Applied Sciences
In recent years, software development models have undergone changes. In order to meet user needs and functional changes, open-source software continuously improves its software quality through successive releases. Due to the iterative development process
Jinyong Wang, Ce Zhang
doaj   +1 more source

An NHPP Software Reliability Model with S-Shaped Growth Curve Subject to Random Operating Environments and Optimal Release Time

Applied Sciences, 2017
The failure of a computer system because of a software failure can lead to tremendous losses to society; therefore, software reliability is a critical issue in software development.
Kwang Yoon Song, In Hong Chang, Hoang Pham   +2 more
doaj   +1 more source

An executable software architecture model for response time and reliability assessment [PDF]

Management Science Letters, 2014
With the increasing use of the Unified Modeling Language (UML) diagrams to describe the software’s architecture and the importance of evaluating nonfunctional requirements at the level of software architecture, creating an executable model from these ...
Zahra Norouzi, Ali Harounabadi
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Practical software reliability engineering with the Software Failure and Reliability Assessment Tool (SFRAT)

SoftwareX, 2019
Many large software projects struggle to achieve their reliability targets. Software reliability growth models quantify reliability from failure data collected during software testing.
Vidhyashree Nagaraju, Venkateswaran Shekar, Joshua Steakelum, Melanie Luperon, Ying Shi, Lance Fiondella   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A Markov Reward Model for Software Reliability [PDF]

2007 IEEE International Parallel and Distributed Processing Symposium, 2007
A compositional method for estimating software reliability of many threaded programs is developed. The method uses estimates of the reliability of individual modules and the probability of transitions between the modules to estimate the reliability of a program in terms of its current state.
YoungMin Kwon, Gul Agha
openaire   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source