Results 101 to 110 of about 6,176,166 (267)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Deciding the Criteria for Software Selection: A Bibliometric Review

Journal of Transportation and Logistics
With the increase in global competition, there has been an increase in research on how to increase business efficiency and profitability. One area of focus is how businesses choose which software to use.
Bükra Doğaner Duman, Mehmet Gürtürk, Mehmet Adak, Esma Koç   +3 more
doaj   +1 more source

Review of ArchEd and Stratigraph - Excavation recording and analysis software [Software]

Internet Archaeology, 2000
This review investigates two software packages, ArchEd and Stratigraph, which have been developed to assist with the recording and analysis of archaeological excavations.
Mike Rains
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Wartime Opportunities in Legal Aid Work [PDF]

, 1943
We present the basic idea and setup for some recent methods for System Identification, that also deliver error bounds to the user. In particular, we look at Stochastic Embedding, Set Membership Identification and Model Error Modelling. We review and test
Bradway, John S.
core   +1 more source

Unbounded Human Learning: Optimal Scheduling for Spaced Repetition

, 2016
In the study of human learning, there is broad evidence that our ability to retain information improves with repeated exposure and decays with delay since last exposure.
Chao X., Kelly F. P., Leitner S., Linden W., Pashler H., Rasch G.   +5 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Parallel Distributed Grammar Engineering for Practical Applications [PDF]

, 2011
Based on a detailed case study of parallel grammar development distributed across two sites, we review some of the requirements for regression testing in grammar engineering, summarize our approach to systematic competence and performance profiling, and ...
Bender, Emily M., Callmeier, Uli, Flickinger, Dan, Oepen, Stephan, Siegel, Melanie   +4 more
core  

A Systematic Review of Strong Gravitational Lens Modeling Software

, 2013
Despite expanding research activity in gravitational lens modeling, there is no particular software which is considered a standard. Much of the gravitational lens modeling software is written by individual investigators for their own use.
Aazami, Alan T. Lefor, Alard, Allam, Berciano Alba, Bertin, Boughen, Brewer, Brewer, Coe, Coe, Cohn, Jullo, Jullo, Kneib, Knudson, Liesenborgs, Liesenborgs, Liesenborgs, Liesenborgs, Limousin, Lin, Mohammad Akhlaghi, Newbury, Oguri, Oguri, Peng, Richard, Richard, Saha, Saha, Saha, Smith, Suyu, Toshifumi Futamase, Wallington, Warren, Wayth, Wayth, Williams   +39 more
core   +1 more source