Results 31 to 40 of about 3,923,394 (245)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Notes on fiber length measurements: A case study in the underbelly of open source neuroscience

NeuroImage, 2022
Being on the bleeding edge of research requires the use of new and regularly updated software. The result is the occasional and inevitable occurrence of bugs.
Claude J Bajada, Robert E Smith, Svenja Caspers   +2 more
doaj   +1 more source

Pembuatan Aplikasi Multimedia Untuk Membantu Siswa Sekolah Dasar Dalam Mempelajari Sains [PDF]

, 2010
Science is very important in our everyday lives. That is the reason why students have to learn science since the beginning of their primary school. However, many students find difficulties in studying science.
., Lisana
core  

Inpatient Food Insecurity and Pediatric Hematology Oncology Hospitalization Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Children with cancer and blood disorders are at risk for food insecurity (FI). We aimed to describe the association of inpatient food insecurity (IFI) and hospitalization outcomes among patients admitted to the pediatric hematology oncology service. Of 325 caregivers screened for IFI, 60 (18.6%) screened positive.
Joanna M. Robles, Greg Russell, Leila H. DeWitt, Kimberly Montez, Callie L. Brown   +4 more
wiley   +1 more source

Project for advancement of software usability in materials science

Science and Technology of Advanced Materials: Methods
The Institute for Solid State Physics (ISSP) at The University of Tokyo has been carrying out a software development project named ‘the Project for Advancement of Software Usability in Materials Science (PASUMS)’. Since the launch of PASUMS, various open-
Kazuyoshi Yoshimi, Yuichi Motoyama, Tatsumi Aoyama, Mitsuaki Kawamura, Naoki Kawashima   +4 more
doaj   +1 more source

Differential Evolution Algorithm With Tracking Mechanism and Backtracking Mechanism

IEEE Access, 2018
Differential evolution (DE) is a simple and effective evolutionary algorithm that can be used to solve various optimization problems. In general, the population of DE tends to fall into stagnation or premature convergence so that it is unable to converge
Laizhong Cui, Qiuling Huang, Genghui Li, Shu Yang, Zhong Ming, Zhenkun Wen, Nan Lu, Jian Lu   +7 more
doaj   +1 more source

Dynamic Multiobjective Optimization with Multiple Response Strategies Based on Linear Environment Detection

Complexity, 2020
Dynamic multiobjective optimization problems (DMOPs) bring more challenges for multiobjective evolutionary algorithm (MOEA) due to its time-varying characteristic.
Qiyuan Yu, Shen Zhong, Zun Liu, Qiuzhen Lin, Peizhi Huang   +4 more
doaj   +1 more source

Towards reproducible software studies with MAO and Renku

SoftwareX, 2022
In software engineering, the developers’ joy of decomposing and recomposing microservice-based applications has led to an enormous wave of microservice artefact technologies.
Josef Spillner, Panagiotis Gkikopoulos, Pamela Delgado, Christine Choirat   +3 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source