Results 41 to 50 of about 2,411,480 (264)

MATADOR: a magic matrix-based framework for tamper detection and image recovery

Journal of King Saud University: Computer and Information Sciences
Ensuring the integrity and authenticity of digital medical images is crucial for healthcare security and digital forensics, as image tampering can have serious consequences.
Thilina Mendis, Farah Kandah, Lalith Medury   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Dataset for Single Character Detection in Dongba Manuscripts

Scientific Data
The Dongba script, a unique pictographic writing system invented by the ancestors of the Naxi people of China, holds great significance for interpreting the ancient Naxi language, history, and culture.
Yuqi Ma, Yongbo Li, Guang Long, Ruiyuan Li, Fengyuan Hu, Chenjun Xu, Yueran Wang, Maoling Peng, Xiaoliang Li, Shanxiong Chen   +9 more
doaj   +1 more source

A Novel Hybrid Multi-Objective Particle Swarm Optimization Algorithm With an Adaptive Resource Allocation Strategy

IEEE Access, 2019
Recently, there are a number of particle swarm optimization algorithms (PSOs) proposed for tackling multi-objective optimization problems (MOPs). Most of multi-objective PSOs (MOPSOs) were designed to speed up their convergence, which have been validated
Lingjie Li, Shuo Chen, Zhe Gong, Qiuzhen Lin, Zhong Ming   +4 more
doaj   +1 more source

Data Science: Technologies for Better Software [PDF]

IEEE Software, 2019
Data science is mandatory in today's business to capitalize on achievements and assets. This specifically holds for modern software development, where data science facilitates analyzing product, process, and usage and thus managing evolution and performance.
Christof Ebert, Jens Heidrich, Silverio Martínez-Fernández, Adam Trendowicz   +3 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An Empirical Process Model for Agile Practitioners Developing Healthcare Software

IET Software
Agile philosophy emphasises flexibility, adaptability and human-centred software development. However, in medical software development, integrating regulatory compliance and safety-critical requirements within Agile methods introduces significant tension.
Yazidu Buba Salihu, Julian Michael Bass, Gloria Ejehiohen Iyawa   +2 more
doaj   +1 more source

Semantic representation of scientific literature: bringing claims, contributions and named entities onto the Linked Open Data cloud [PDF]

PeerJ Computer Science, 2015
Motivation. Finding relevant scientific literature is one of the essential tasks researchers are facing on a daily basis. Digital libraries and web information retrieval techniques provide rapid access to a vast amount of scientific literature.
Bahar Sateli, René Witte
doaj   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source