Results 111 to 120 of about 436,934 (300)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Modeling and simulation of Khat waste fast pyrolysis for energy recovery

Heliyon
Bioenergy is now recognized to be capable of providing the vast majority of predicted future renewable energy supply. Biomass is currently considered a common and commonly used renewable energy source.
Geleta Afessa Moreda, Sorome Deresa Tolasa, Debela Alema Teklemariyem   +2 more
doaj   +1 more source

Performance evaluation of Atmotube PRO sensors for air quality measurements in an urban location [PDF]

Atmospheric Measurement Techniques
This study presents a performance evaluation of eight Atmotube PRO sensors using US Environmental Protection Agency (US EPA) guidelines. The Atmotube PRO sensors were collocated side by side with a reference-grade Fidas monitor in an outdoor setting for ...
A. I. Shittu, A. I. Shittu, K. J. Pringle, S. R. Arnold, R. J. Pope, R. J. Pope, A. M. Graham, C. Reddington, R. Rigby, J. B. McQuaid   +9 more
doaj   +1 more source

Investigating different strategies for increasing sales and customer base [PDF]

, 2018
The study primarily discusses about the different strategies that the management of the company can implement in order to boost their customer base and net sales.
Kaur, Komalpreet, Okoro, Ogechi
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Software Sustainability Institute - Fellowship Programme 2019 - Launch Webinar

, 2019
Funders: UK Engineering and Physical Sciences Research Council (EPSRC) through grant EP/H043160/1 and EPSRC, BBSRC and ESRC Grant EP/N006410/1.
openaire   +1 more source

The Karlskrona manifesto for sustainability design [PDF]

, 2014
Sustainability is a central concern for our society, and software systems increasingly play a central role in it. As designers of software technology, we cause change and are responsible for the effects of our design choices. We recognize that there is a
Becker, Christoph, Betz, Stefanie, Calero, Coral, Chitchyan, Ruzanna, Duboc, Leticia, Easterbrook, Steve, Kocak, Sedef Akinli, Mahaux, Martin, Penzenstadler, Birgit, Rodriguez-Navas, Guillermo, Salinesi, Camille, Seyff, Norbert, Venters, Colin   +12 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The Future of Hackathon Research and Practice

IEEE Access
Hackathons are time-bounded collaborative events that have become a global phenomenon and are adopted by researchers and practitioners in a plethora of contexts.
Jeanette Falk, Alexander Nolte, Daniela Huppenkothen, Marion Weinzierl, Kiev Gama, Daniel Spikol, Erik Tollerud, Neil P. Chue Hong, Ines Knapper, Linda Bailey Hayden   +9 more
doaj   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source