Results 91 to 100 of about 79,297 (257)

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Advancing Aspect-Based Sentiment Analysis in Course Evaluation: A Multi-Task Learning Framework With Selective Paraphrasing

IEEE Access
Aspect-based sentiment analysis (ABSA) is essential for extracting valuable perspectives from textual data, particularly within educational contexts where understanding student feedback is vital for course evaluation.
Shahla Gul, Muhammad Asif, Fazal-E- Amin, Kashif Saleem, Muhammad Imran   +4 more
doaj   +1 more source

Software Sustainability Institute - Fellowship Programme 2020 - Launch Webinar

, 2019
The Software Sustainability Institute's Fellowship Programme funds researchers, software engineers and advocates who want to improve computational practice in their areas of work. The Launch Webinar is an opportunity to present more about the Institute, the programme and the application process, and hear from our existing Fellows about their ...
openaire   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Software Sustainability Institute - Fellowship Programme 2019 - Launch Webinar

, 2019
Funders: UK Engineering and Physical Sciences Research Council (EPSRC) through grant EP/H043160/1 and EPSRC, BBSRC and ESRC Grant EP/N006410/1.
openaire   +2 more sources

Better Software, Better Research: How the Software Sustainability Institute is helping to promote reproducible research

, 2020
I delivered this presentation at the Beware: Results May Vary - Openness as a Way of Enhancing Research Quality workshop at the University of Manchester on 28 February 2020.Eventbrite: https://www.eventbrite.co.uk/e/beware-results-may-vary-openness-as-a-way-of-enhancing-research-quality-tickets-83813734135HackMD: https://hackmd.io/@ajstewartlang/r1ec ...
openaire   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Detailed Design of Special-Shaped Steel Structures Based on DfMA: The BIM-FEM Model Conversion Method

Buildings
(1) This paper, based on the characteristics of complex steel structures as well as difficult points in the process of their detailed design, introduces the product design concept of DfMA (Design for Manufacturing and Assembly) from the manufacturing ...
Yiquan Zou, Feng Hu, Hao Yang, Jie Cai, Han Pan, Qin Zhang   +5 more
doaj   +1 more source