Results 81 to 90 of about 79,297 (257)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

THE REALITY OF AGROTOURISM AND THE CHALLENGES OF LOCAL DEVELOPMENT IN BOUMERDES PROVINCE: FOUNDATIONS AND OPPORTUNITIES FOR SUSTAINABLE AGRICULTURAL DEVELOPMENT [PDF]

Geo Journal of Tourism and Geosites
Agriculture plays a pivotal role in ensuring food security and providing employment opportunities, while tourism is a strategic element in economic development, especially in resource-rich countries like Algeria, which boasts unique tourism potential
Zineb MAAMAR*, Mona ABBADIE
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Activities and Experiences from the UK Software Sustainability Institute

, 2015
Invited talk at the User Support workshop at the Nordic e-Infrastructure Conference 2015, describing the different reasons and mechanisms the Software Sustainability Institute deploys to engage the research communities who rely on research software.
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The Role of Environmental Management Systems in Enhancing the Competitive Advantage of Educational Institutions in Light of the Green Economy: A Case Study on Future Higher Institute for Specialized Technological Studies

Journal of Environmental Science
:This study aims to analyze the role of environmental management systems (EMS) in enhancing the competitive advantage of educational institutions in light of global shifts toward the green economy, applying it to the Future Higher Institute for ...
Tharwat Zaki, Osama Farid, Seham Sherif
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Multi-site short-term wind-component forecasting with hybrid adaptive spatiotemporal domain-informed neural network

Energy and AI
Modeling the behavior of wind in the atmosphere is a long-term ambition for humanity and an indispensable initiative to promote wind energy. The real challenge lies in the high complexity of modeling non-linear dynamic systems to simulate intermittent ...
Henrique Ávila Santos, Prashant Kumar, Idelfonso Nogueira, Simon See, Erick Giovani Sperandio Nascimento   +4 more
doaj   +1 more source

Introduction to the Software Sustainability Institute for new Fellows

, 2017
Introduction to the Institute given at the Fellows 2017 inauguration meeting in Edinburgh on 26th January 2017.
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source