Results 71 to 80 of about 79,297 (257)

Software Sustainability Institute: work & impact

, 2020
A short presentation on the work of the Software Sustainability Institute and its impact on the scientific community for the Sustainable Software in HEP Workshop.
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Multi-scalar risk drivers for a heat vulnerability assessment framework using machine learning algorithms

Scientific Reports
This study aims to address the challenge of quantifying amplified heat-related health risks in tropical nations by developing and validating a novel, data-driven framework in Malaysia to deconstruct the complex interplay between social vulnerability and ...
Zecheng Li, Chng Saun Fong, Nasrin Aghamohammadi, Nik Meriam Sulaiman, Siti Hafizah Ab Hamid   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Enablers and Barriers of a Cross-Cultural Geriatric Education Distance Training Programme: The Singapore-Uganda Experience

Geriatrics, 2020
Background: By 2050, 80% of the world’s older population will reside in developing countries. There is a need for culturally appropriate training programs to increase awareness of eldercare issues, promote knowledge of how to better allocate resources to
Ngoc Huong Lien Ha, Xin Ying Chua, Shallon Musimenta, Edith Akankwasa, Nongluck Pussayapibul, Hui Jin Toh, Mimaika Luluina Ginting, Dujeepa D. Samarasekera, Wai Jia Tam, Philip Lin Kiat Yap, James Alvin Yiew Hock Low   +10 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

EROIKA: Enhanced Recognition of Intrusion Key Actors—A Multi-Stage Botnet Detection Framework With Conditional Autoencoder and Communication Pattern Analysis

IEEE Open Journal of the Communications Society
Botnets pose a persistent and significant threat to network security by concealing their presence within legitimate traffic and executing various attacks, including distributed denial-of-service (DDoS) assaults, phishing schemes, and malware ...
Muhammad Aidiel Rachman PUTRA, Tohari Ahmad, Takashi Obi, Joong-Sun Lee, Yi-Na Jeong, Dandy Pramana Hostiadi, Royyana Muslim Ijtihadie   +6 more
doaj   +1 more source

Better software, Better research: ?how has the Software Sustainability Institute ?changed research software practice?

, 2023
Research Is now reliant on software, but many researchers have not received a lot of formal training in software development. The Software Sustainability Institute (SSI) was established in the United Kingdom in 2010 to “cultivate better, more sustainable, research software to enable world-class research”.
openaire   +1 more source