Results 131 to 140 of about 1,093,401 (218)

Improved MeSH analysis software tools for farm animals. [PDF]

Anim Genet, 2022
Amorim ST, Tsuyuzaki K, Nikaido I, Morota G.   +3 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

AI-based hardware and software tools in microscopy to boost research in immunology and virology. [PDF]

Front Immunol
Morone D, D'Antuono R.
europepmc   +1 more source

Correction: Web-Based Software Tools for Systematic Literature Review in Medicine: Systematic Search and Feature Analysis. [PDF]

JMIR Med Inform, 2022
Cowie K, Rahmatullah A, Hardy N, Holub K, Kallmes K.   +4 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Quantitative bias analysis for mismeasured variables in health research: a review of software tools. [PDF]

BMC Med Res Methodol
Gerlach-Wood CJC, Tilling K, Bartlett JW, Hughes RA.   +3 more
europepmc   +1 more source

Editorial: Scalable Bioinformatics: Methods, Software Tools, and Hardware Architectures. [PDF]

Front Genet, 2021
Alachiotis N, Low TM, Pavlidis P.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

PERC: a suite of software tools for the curation of cryoEM data with application to simulation, modeling and machine learning. [PDF]

Acta Crystallogr F Struct Biol Commun
Costa-Gomes B, Greer J, Juraschko N, Parkhurst J, Mirecka J, Famili M, Rangel-Smith C, Strickson O, Lowe A, Basham M, Burnley T.   +10 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source