Results 121 to 130 of about 1,535,898 (372)

Recovery from acidosis is a robust trigger for loss of force in murine hypokalemic periodic paralysis. [PDF]

, 2019
Periodic paralysis is an ion channelopathy of skeletal muscle in which recurrent episodes of weakness or paralysis are caused by sustained depolarization of the resting potential and thus reduction of fiber excitability.
Cannon, Stephen C, DiFranco, Marino, Mi, Wentao, Quinonez, Marbella, Wu, Fenfen   +4 more
core   +1 more source

Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis [PDF]

, 1990
An abnormal ratio between Na+ and K+ conductances seems to be the cause for the depolarization and paralysis of skeletal muscle in primary hypokalemic periodic paralysis.
Ballanyi, Beam, Bretag, Cook, Engel, Escande, Fosset, Hamilton, Huang, Iaizzo, Lehmann-Horn, Quasthoff, Ruff, Ruff, R�del, R�del, Sanguinetti, Spuler, Sturgess, Tanabe   +19 more
core   +1 more source

Morphological differences in myofibre size and shape: A comparative study of the soleus, gastrocnemius, triceps brachii and vastus lateralis in humans and mice

Journal of Anatomy, EarlyView.
Myofibre size and shape were investigated in functionally distinct muscles of humans and mice using ATPase histochemistry and immunofluorescence. In both species, soleus myofibres were found to be larger, more irregularly shaped, and more heterogeneous compared to other muscles. These findings may have implications for biomedical research and potential
Casper Soendenbroe, Rene B. Svensson, Bettina Mittendorfer, S. Peter Magnusson, Abigail L. Mackey, Jesper L. Andersen   +5 more
wiley   +1 more source

CXCL12/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axonterminals [PDF]

, 2017
The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter-cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins.
Aram Megighian, Bagri A, Cesare Montecucco, Chiara M Mazzanti, Egle Radice, Elisa Duregotti, Elisanna Bergamin, Francesca Lessi, Guyon A, Marco La Ferla, Marco Pirazzini, Marcus Thelen, Michela Rigoni, Michele Menicagli, Paolo Aretini, Samuele Negro, Sara Franceschi, Shellard A   +17 more
core   +1 more source

Skeletal muscle mitochondrial correlates of critical power and W' in healthy active individuals

Experimental Physiology, EarlyView.
Abstract The asymptote (critical power; CP) and curvature constant (W') of the hyperbolic power–duration relationship can predict performance within the severe‐intensity exercise domain. However, the extent to which these parameters relate to skeletal muscle mitochondrial content and respiratory function is not known.
Donald L. Peden, Robert Rogers, Emma A. Mitchell, Suzanne M. Taylor, Stephen J. Bailey, Richard A. Ferguson   +5 more
wiley   +1 more source

Hypertrophy Stimulation at the Onset of Type I Diabetes Maintains the Soleus but Not the EDL Muscle Mass in Wistar Rats

Frontiers in Physiology, 2017
Diabetes mellitus induces a reduction in skeletal muscle mass and strength. Strength training is prescribed as part of treatment since it improves glycemic control and promotes increase of skeletal muscle mass. The mechanisms involved in overload-induced
Marco A. S. Fortes, Maria V. M. Scervino, Gabriel N. Marzuca-Nassr, Gabriel N. Marzuca-Nassr, Kaio F. Vitzel, Carlos H. da Justa Pinheiro, Rui Curi, Rui Curi   +7 more
doaj   +1 more source

Single muscle fiber proteomics reveals unexpected mitochondrial specialization [PDF]

, 2015
Mammalian skeletal muscles are composed of multinucleated cells termed slow or fast fibers according to their contractile and metabolic properties. Here, we developed a high-sensitivity workflow to characterize the proteome of single fibers.
A. S., Deshmukh, Cancellara, Pasqua, I., Moretti, M., Mann, M., Zeiler, Murgia, Marta, N., Nagaraj, Reggiani, Carlo, Schiaffino, Stefano   +8 more
core   +1 more source

Blood flow restriction: The acute effects of body tilting and reduced gravity analogues on limb occlusion pressure

Experimental Physiology, EarlyView.
Abstract Blood flow restriction (BFR) has been identified as a potential countermeasure to mitigate physiological deconditioning during spaceflight. Guidelines recommend that tourniquet pressure be prescribed relative to limb occlusion pressure (LOP); however, it is unclear whether body tilting or reduced gravity analogues influence LOP.
Patrick Swain, Nick Caplan, Luke Hughes
wiley   +1 more source

GSK3 inhibition with low dose lithium supplementation augments murine muscle fatigue resistance and specific force production

Physiological Reports, 2020
Calcineurin is a Ca2+‐dependent serine/threonine phosphatase that dephosphorylates nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus.
Kennedy C. Whitley, Sophie I. Hamstra, Ryan W. Baranowski, Colton J. F. Watson, Rebecca E. K. MacPherson, Adam J. MacNeil, Brian D. Roy, Rene Vandenboom, Val A. Fajardo   +8 more
doaj   +1 more source

Kinematic, kinetic and electromyographic response to customized foot orthoses in patients with tibialis posterior tenosynovitis, pes plano valgus and rheumatoid arthritis [PDF]

, 2013
Objective. To describe the effect of customized foot orthoses (FOs) on the kinematic, kinetic and EMG features in patients with RA, tibialis posterior (TP) tenosynovitis and associated pes plano valgus.<p></p> Methods. Patients with RA and
Barn, R., Brandon, M., Rafferty, D., Steultjens, M., Sturrock, R.D., Turner, D.E., Woodburn, J.   +6 more
core   +1 more source