Results 41 to 50 of about 62,363 (313)

Dietary nitrate preserves mitochondrial bioenergetics and mitochondrial protein synthesis rates during short‐term immobilization in mice

open access: yesThe Journal of Physiology, EarlyView., 2023
Abstract figure legend In female mice consuming standard drinking water (H2O), 3 and 7 days of single‐limb immobilization (immob) decreased mitochondrial (mito) protein fractional synthesis rate (FSR), myofibrillar (myofib) protein FSR, and mitochondrial respiration, in addition to increasing mitochondrial reactive oxygen species (ROS).
Heather L. Petrick   +8 more
wiley   +1 more source

In Vivo Reprogramming of Tissue‐Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering

open access: yesAdvanced Science, EarlyView.
Inspired by exercise‐induced metabolic rewiring and EV secretion, this study shows that in vivo metabolic engineering strategy can reprogram EV secretion pattern and simultaneously attenuate multiple tissue injury in CKD status, highlighting that it is a potential strategy for treating diverse chronic diseases.
Meng Zhao   +11 more
wiley   +1 more source

Electrical stimulated GLUT4 signalling attenuates critical illness‐associated muscle wasting

open access: yesJournal of Cachexia, Sarcopenia and Muscle, 2022
Background Critical illness myopathy (CIM) is a debilitating condition characterized by the preferential loss of the motor protein myosin. CIM is a by‐product of critical care, attributed to impaired recovery, long‐term complications, and mortality.
Alex B. Addinsall   +6 more
doaj   +1 more source

Soleus H-reflex Excitability Changes in Response to Sinusoidal Hip Stretches in the Injured Human Spinal Cord [PDF]

open access: yes, 2007
Imposed static hip stretches substantially modulate the soleus H-reflex in people with an intact or injured spinal cord while stretch of the hip flexors affect the walking pattern in lower vertebrates and humans.
Chaudhuri, Debjani   +4 more
core   +2 more sources

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

open access: yesAdvanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao   +15 more
wiley   +1 more source

Resistance exercise reduced the expression of fibroblast growth factor-2 in skeletal muscle of aged mice

open access: yesIntegrative Medicine Research, 2016
Background: Fibroblast growth factor-2 (FGF-2) protein level has been shown to be elevated in aged mice muscle compared to adult mice. It activates the satellite cell quiescence, which leads to satellite cell depletion and may accelerate aging process ...
Jin-Soo Kim   +4 more
doaj   +1 more source

Parallel Facilitatory Reflex Pathways from the Foot and Hip to Flexors and Extensors in the Injured Human Spinal Cord [PDF]

open access: yes, 2007
Spinal integration of sensory signals associated with hip position, muscle loading, and cutaneous sensation of the foot contributes to movement regulation.
Kay, Elizabeth   +2 more
core   +2 more sources

Effects of the Dietary Supplement 5α‐Hydroxy‐Laxogenin in the Orchiectomized Rat Model

open access: yesDrug Testing and Analysis, EarlyView.
The dietary supplement ingredient 5α‐hydroxy‐laxogenin was investigated in the castrated male rat for potential androgenic and anabolic effects. Moreover, androgen receptor binding of 5α‐hydroxy‐laxogenin was modelled by in silico docking. While molecular modelling supports androgen receptor binding, we observed neither androgenic nor anabolic effects ...
Daniel Derwand   +4 more
wiley   +1 more source

The p21‐activated kinase 2 (PAK2), but not PAK1, regulates contraction‐stimulated skeletal muscle glucose transport

open access: yesPhysiological Reports, 2020
Aim Muscle contraction stimulates skeletal muscle glucose transport. Since it occurs independently of insulin, it is an important alternative pathway to increase glucose transport in insulin‐resistant states, but the intracellular signaling mechanisms ...
Lisbeth L. V. Møller   +6 more
doaj   +1 more source

Impacts of Cigarette Smoke (CS) on Muscle Derangement in Rodents—A Systematic Review

open access: yesToxics, 2022
Cigarette smoke (CS) is the major risk factor for chronic obstructive pulmonary disease (COPD) and can induce systemic manifestations, such as skeletal muscle derangement.
Aaron W. J. He   +5 more
doaj   +1 more source

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