Results 81 to 90 of about 1,535,898 (372)
Predictive Factors of Free Flap Volume Evolution in Head and Neck Reconstruction
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective The aim of our study was to determine the factors influencing the evolution of the total volume and bone volume of free flaps commonly used in head and neck surgery, with a 30‐month prospective study, to establish volume change predictions and thus propose a degree of overcorrection to be expected before reconstruction.
Quentin Hennocq +10 more
wiley +1 more source
The effects of hibernation on the contractile and biochemical properties of skeletal muscles in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus [PDF]
, 2013 Hibernation is a crucial strategy of winter survival used by many mammals. During hibernation, thirteen-lined ground squirrels, Ictidomys tridecemlineatus, cycle through a series of torpor bouts, each lasting more than a week, during which the animals ...
Allan +45 more
core +2 more sources
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.Abstract Quantitative model‐based clinical trial simulation tools play a critical role in informing study designs through simulation before actual execution. These tools help drug developers explore various trial scenarios in silico to select a clinical trial design to detect therapeutic effects more efficiently, therefore reducing time, expense, and ...
Jongjin Kim +10 more
wiley +1 more source
Effect of passive stretching on the immobilized soleus muscle fiber morphology
Brazilian Journal of Medical and Biological Research, 2004 The aim of the present study was to determine the effect of stretching applied every 3 days to the soleus muscle immobilized in the shortened position on muscle fiber morphology. Eighteen 16-week-old Wistar rats were used and divided into three groups of
Coutinho E.L. +4 more
doaj
Short-term creatine supplementation changes protein metabolism signaling in hindlimb suspension
Brazilian Journal of Medical and Biological ResearchThe effect of a short-term creatine supplementation on hindlimb suspension (HS)-induced muscle atrophy was investigated. Creatine monohydrate (5 g/kg b.w. per day) or placebo, divided in 2 daily doses, was given by oral gavage for 5 days.
G.N. Marzuca-Nassr +7 more
doaj +1 more source
PLoS ONE, 2018 Sclerostin is a circulating osteocyte-derived glycoprotein that negatively regulates Wnt-signaling after binding the LRP5/LRP6 co-receptors. Pharmacologic sclerostin inhibition produces bone anabolic effects after spinal cord injury (SCI), however, the ...
Ean G Phillips +9 more
doaj +1 more source
Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats
Aging Cell, EarlyView.Cardiorespiratory fitness (CRF) is not associated with epigenetic clocks, including newly developed ones. On the other hand, CRF is associated with global methylation profiles and promoter methylation in organ‐specific and organ‐common manner. ABSTRACT Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a ...
Takuji Kawamura +15 more
wiley +1 more source
Aging Cell, EarlyView.Supplementation with the natural senolytic agent fisetin attenuated age‐related declines in physical function in mice. Better physical function with fisetin was accompanied by lower expression of cell senescence‐related genes. Fisetin treatment had comparable effects on physical function as genetic clearance of senescent cells and synthetic senolytic ...
Kevin O. Murray +10 more
wiley +1 more source
Investigation of the Expression of Myogenic Transcription Factors, microRNAs and Muscle-Specific E3 Ubiquitin Ligases in the Medial Gastrocnemius and Soleus Muscles following Peripheral Nerve Injury. [PDF]
PLoS ONE, 2015 Despite surgical innovation, the sensory and motor outcome after a peripheral nerve injury remains incomplete. One contributing factor to the poor outcome is prolonged denervation of the target organ, leading to apoptosis of both mature myofibres and ...
Rebecca Wiberg +3 more
doaj +1 more source
Journal of applied physiology, 2011 The orientation of muscle fibers influences the physiological cross-sectional area, the relationship between fiber shortening and aponeurosis shear, and the total force produced by the muscle.
U. Sinha +3 more
semanticscholar +1 more source