Results 61 to 70 of about 474,226 (299)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Low Friction and High Solid-Solid Contact Ratio—A Contradiction for Laser-Patterned Surfaces?

Lubricants, 2017
Recording of Stribeck-like curves is a common way to study the effect of laser-patterned surfaces on the frictional efficiency. However, solely relying on the coefficient of friction when identifying the lubrication regime and the underlying working ...
Simon Bettscheider, Philipp G. Grützmacher, Andreas Rosenkranz   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Creation of prompt and thin-sheet splashing by varying surface roughness or increasing air pressure

, 2012
A liquid drop impacting a solid surface may splash by emitting a thin liquid sheet that subsequently breaks apart or by promptly ejecting droplets from the advancing liquid-solid contact line.
Andrzej Latka, Ariana Strandburg-Peshkin, Cacey S. Stevens, Michelle M. Driscoll, R. Rioboo, Sidney R. Nagel   +5 more
core   +1 more source

Fast synthesis of platinum nanopetals and nanospheres for highly-sensitive non-enzymatic detection of glucose and selective sensing of ions [PDF]

, 2015
Novel methods to obtain Pt nanostructured electrodes have raised particular interest due to their high performance in electrochemistry. Several nanostructuration methods proposed in the literature use costly and bulky equipment or are time-consuming due ...
A Craggs, A Michalska, A Ott, BI Kharisov, C Nardini, C-Z Lai, D Wen, G Lu, H Heli, H Kawasaki, H Wallberg-Henriksson, H Zhang, H Zhang, H Zhou, HM Yasin, J Ping, J Ren, J Shi, J Wang, J Xie, J-H Han, JM Wu, K Doyeon, K Kerman, KE Toghill, L Plyasova, M Guo, MA Cooper, MA Fierke, RC Barry, S Park, S Park, S Park, S Park, S-H Yoo, TA Zangle, W Yang, X Wu, Y Wang, YW Lee   +39 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Drying microcharacteristics of volatile and non-volatile droplets on smooth and structured surfaces [PDF]

E3S Web of Conferences
In order to analyze the dynamics of droplet evaporation from solid surfaces and to study the liquid-solid interactions, liquid droplets were deposited on substrates and examined under a microscope.
Peschenyuk Yulia A., Ayvazyan Gagik Y., Gatapova Elizaveta Ya.   +2 more
doaj   +1 more source

Epoxy–amine/metal interphases: Influences from sharp needle-like crystal formation [PDF]

, 2007
When epoxy–amine liquid mixtures are applied onto metallic oxide layer, concomitant amine chemical sorption and metallic surface dissolution appear leading to the organo-metallic complex formation.
Alain André Roche, Aufray, Barthès-Labrousse, Benabdi, Benabdi, Bentadjine, Bentadjine, Bouchet, Bouchet, Fauquet, Kanzow, Maëlenn Aufray, Montois, Possart, Roche   +14 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source