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Rescalable solid-state nanopores
AIP Conference Proceedings, 2017Nanopores in 10–30 nm thickness Si4N3 membranes were milled using Ga+ ions. Dose dependence of the hole diameter and shape was established and explained as resulting from the intensity distribution of the focused ion beam. The initial diameter of the milled pore is dependent on the full-width half-maximum of the axial portion of the beam, whereas shape
Armandas Balčytis +4 more
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Microfluidic multiplexing of solid-state nanopores
Journal of Physics: Condensed Matter, 2017Although solid-state nanopores enable electronic analysis of many clinically and biologically relevant molecular structures, there are few existing device architectures that enable high-throughput measurement of solid-state nanopores. Herein, we report a method for microfluidic integration of multiple solid-state nanopores at a high density of one ...
Tarun Jain +4 more
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Recent Progress in Solid‐State Nanopores
Advanced Materials, 2018AbstractThe solid‐state nanopore has attracted much attention as a next‐generation DNA sequencing tool or a single‐molecule biosensor platform with its high sensitivity of biomolecule detection. The platform has advantages of processability, robustness of the device, and flexibility in the nanopore dimensions as compared with the protein nanopore, but ...
Kidan Lee +6 more
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Nature Nanotechnology, 2007
The passage of individual molecules through nanosized pores in membranes is central to many processes in biology. Previously, experiments have been restricted to naturally occurring nanopores, but advances in technology now allow artificial solid-state nanopores to be fabricated in insulating membranes.
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The passage of individual molecules through nanosized pores in membranes is central to many processes in biology. Previously, experiments have been restricted to naturally occurring nanopores, but advances in technology now allow artificial solid-state nanopores to be fabricated in insulating membranes.
openaire +2 more sources
Solid-State Nanopore Technologies for Nanopore-Based DNA Analysis
Nanomedicine, 2007Nanopore-based DNA analysis is a new single-molecule technique that involves monitoring the flow of ions through a narrow pore, and detecting changes in this flow as DNA molecules also pass through the pore. It has the potential to carry out a range of laboratory and medical DNA analyses, orders of magnitude faster than current methods.
Ken, Healy +2 more
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DNA Origami Gatekeepers for Solid‐State Nanopores
Angewandte Chemie, 2012DNA has it covered: DNA origami gatekeeper nanoplates convert nanopores in solid-state membranes into versatile devices for label-free macromolecular sensing applications. The custom apertures in the nanoplates can be chemically addressed for sequence-specific detection of DNA.
Ruoshan Wei +3 more
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Solid-state nanopores and nanopore arrays optimized for optical detection
Nanoscale, 2014Controllable reduction of the local fluorescence around solid-state nanopores and nanopore arrays enables optical recognition of molecular translocations and a route towards massively-parallel detection.
Furat, Sawafta +4 more
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Selective (Bio)Functionalization of Solid-State Nanopores
ACS Applied Materials & Interfaces, 2015We present a method to selectively (bio)functionalize nanoscale features with the same materials chemistry. It was successfully combined with nanosphere lithography to fabricate and functionalize solid-state nanopores with PEG-brushes, supported lipid membranes, and functional proteins over large areas.
Pla-Roca Mateu +3 more
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DNA-functionalized solid state nanopore for biosensing
Nanotechnology, 2010The possible use of nanopores for single DNA molecules biosensing has been demonstrated, but much remains to do in order to develop advanced engineered devices with enhanced stability, and controlled geometry and surface properties. Here we present morphological and electrical characterization of solid state silicon nitride nanopores fabricated by ...
MUSSI, VALENTINA +7 more
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Solid state nanopores for gene expression profiling
Superlattices and Microstructures, 2009Abstract Recently, nanopore technology has been introduced for genome analysis. Here we show results related to the possibility of preparing “engineered solid state nanopores”. The nanopores were fabricated on a suspended Si 3 N 4 membrane by Focused Ion Beam (FIB) drilling and chemically functionalized in order to covalently bind oligonucleotides ...
MUSSI, VALENTINA +7 more
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