Results 31 to 40 of about 757,777 (265)

Involvement of microRNA in Solid Cancer: Role and Regulatory Mechanisms

Biomedicines, 2021
MicroRNAs (miRNAs) function as the post-transcriptional factor that finetunes the gene expression by targeting to the specific candidate. Mis-regulated expression of miRNAs consequently disturbs gene expression profile, which serves as the pivotal ...
Ying-Chin Lin, Tso-Hsiao Chen, Yu-Min Huang, Po-Li Wei, Jung-Chun Lin   +4 more
doaj   +1 more source

The clinical role of the TME in solid cancer [PDF]

British Journal of Cancer, 2018
The highly complex and heterogenous ecosystem of a tumour not only contains malignant cells, but also interacting cells from the host such as endothelial cells, stromal fibroblasts, and a variety of immune cells that control tumour growth and invasion.
Giraldo, Nicolas, Sanchez-Salas, Rafael, Peske, J David, Vano, Yann, Becht, Etienne, Petitprez, Florent, Validire, Pierre, Ingels, Alexandre, Cathelineau, Xavier, Fridman, Wolf Herman, Sautès-Fridman, Catherine   +10 more
openaire   +3 more sources

Current advances in cancer vaccines targeting NY-ESO-1 for solid cancer treatment

Frontiers in Immunology, 2023
New York-esophageal cancer 1 (NY-ESO-1) belongs to the cancer testis antigen (CTA) family, and has been identified as one of the most immunogenic tumor-associated antigens (TAAs) among the family members.
Hong Zhou, Hong Zhou, Hong Zhou, Yipeng Ma, Yipeng Ma, Fenglan Liu, Fenglan Liu, Bin Li, Bin Li, Dongjuan Qiao, Dongjuan Qiao, Peigen Ren, Mingjun Wang, Mingjun Wang   +13 more
doaj   +1 more source

β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers

Frontiers in Pharmacology
Despite advances in cancer treatment, current cancer incidence and prevalence still demand multimodal treatments to enhance survival and clinical outcomes. Drugs used in cardiology, such as β-blockers and statins have gained attention for their potential
Pedro Gabriel Senger Braga, Pedro Gabriel Senger Braga, Janaína da Silva Vieira, Janaína da Silva Vieira, Aline Rachel Bezerra Gurgel, Aline Rachel Bezerra Gurgel, Patricia Chakur Brum, Patricia Chakur Brum   +7 more
doaj   +1 more source

Survival differences between women and men in the non-reproductive cancers: Results from a matched analysis of the surveillance, epidemiology, and end-results program

Frontiers in Public Health, 2023
BackgroundMen with non-reproductive cancers have a discrepant outcome compared to women. However, they differ significantly in the incidence of cancer type and characteristics.MethodsPatients with single primary cancer who were 18 years or older and ...
Felipe Andrés Cordero da Luz, Felipe Andrés Cordero da Luz, Camila Piqui Nascimento, Eduarda da Costa Marinho, Pollyana Júnia Felicidade, Rafael Mathias Antonioli, Rogério Agenor de Araújo, Rogério Agenor de Araújo, Rogério Agenor de Araújo, Marcelo José Barbosa Silva   +9 more
doaj   +1 more source

Cancer therapy finds a solid target [PDF]

Canadian Medical Association Journal, 2005
Most molecular targets for treating cancer prove to be busts. Broadly applicable anticancer therapies have been particularly difficult to develop because of the multiplicity of genetic mutations in a cancer cell: target one mutation and another will slip by, potentially causing the therapy to ...
openaire   +2 more sources

The Prediction Potential of the Pretreatment Lung Immune Prognostic Index for the Therapeutic Outcomes of Immune Checkpoint Inhibitors in Patients With Solid Cancer: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2021
BackgroundThe lung immune prognostic index (LIPI) is recently developed to predict immune checkpoint inhibitors (ICIs) treatment outcomes for non-small cell lung cancer. However, its predictive value for other types of cancer remained unclear.
Hui Liu, Xiao-Li Yang, Xiao-Yun Yang, Zhao-Ru Dong, Zhi-Qiang Chen, Jian-Guo Hong, Tao Li, Tao Li   +7 more
doaj   +1 more source

Effect of metachronous primary and secondary solid cancers in patients with multiple myeloma: a retrospective study from a single-center

Frontiers in Immunology
Statement of translational relevanceEffects of metachronous primary malignant solid tumor (MPMST) on survival risk and prognosis of multiple myeloma (MM) and differences between MPMST occurring before and after MM remains unclear.
Yunfei Ji, Yunfei Ji, Yunfei Ji, Hujun Li, Hujun Li, Hujun Li, Huanxin Zhang, Huanxin Zhang, Huanxin Zhang, Hai Cheng, Hai Cheng, Hai Cheng, Ying Wang, Ying Wang, Ying Wang, Kailin Xu, Kailin Xu, Kailin Xu, Zhenyu Li, Zhenyu Li, Zhenyu Li   +20 more
doaj   +1 more source

Clonal Hematopoiesis and Solid Cancers

Cancer Science
ABSTRACTClonal hematopoiesis refers to the expansion of hematopoietic stem cells harboring somatic mutations, a phenomenon increasingly recognized in aging populations. This review highlights the emerging relationship between clonal hematopoiesis and solid cancers, focusing on the prevalence and impact of clonal hematopoiesis–associated mutations such ...
Yen T. M. Nguyen, Manabu Fujisawa, Shumpei Ishikawa, Mamiko Sakata‐Yanagimoto   +3 more
openaire   +3 more sources

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source