Results 11 to 20 of about 757,777 (265)
Progression to Metastasis of Solid Cancer [PDF]
Cancers, 2021 Metastatic dissemination of cancer cells, their colonization at distal sites, and ultimate disruption of tissue physiology are the root causes of most deaths from solid cancers, particularly in tumor types where the primary lesion can be easily dissected and discarded [...]
Zacksenhaus, Eldad, Egan, Sean E.
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The role of peroxidasin in solid cancer progression. [PDF]
Biochem Soc Trans, 2023 Peroxidasin is a heme-containing peroxidase enzyme that plays a vital role in the cross-linking of collagen IV molecules in basement membranes. Collagen IV cross-links are essential for providing structure and mechanical stability throughout tissue development, homeostasis, and wound healing. During cancer progression, the basement membrane is degraded,
Wyllie K, Panagopoulos V, Cox TR.
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Shp1 in Solid Cancers and Their Therapy [PDF]
Frontiers in Oncology, 2020 Shp1 is a cytosolic tyrosine phosphatase that regulates a broad range of cellular functions and targets, modulating the flow of information from the cell membrane to the nucleus. While initially studied in the hematopoietic system, research conducted over the past years has expanded our understanding of the biological role of Shp1 to other tissues ...
Alessia Varone +3 more
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Immunotherapy for Metastatic Solid Cancers [PDF]
Advances in Surgery, 2011 After decades of research on solid tumor immunology, immunotherapy has shown effectiveness in patients with metastatic solid cancers. Immune modulators such as IL-2 and anti-CTLA-4 can mediate tumor regression in patients with metastatic melanoma and renal cancer, two tumor types that appear exceptional in their ability to spontaneously harbor ...
Simon, Turcotte, Steven A, Rosenberg
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Solid Cancers and Rheumatoid Arthritis
Cancers, 2023 Since the initial observation that patients with rheumatoid arthritis (RA) have an excess risk of developing hematologic malignancies [...]
George D. Kalliolias +2 more
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Tumour budding in solid cancers
Nature Reviews Clinical Oncology, 2020 Tumour budding is an emerging prognostic biomarker in colorectal cancer (CRC) and other solid cancers. Tumour buds are usually defined as isolated single cancer cells or clusters of up to four cancer cells located at the invasive tumour front. The prognostic value of tumour budding is now supported by a large body of evidence, whereas the utility of ...
Alessandro Lugli +4 more
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STAT3 and STAT5 Activation in Solid Cancers [PDF]
Cancers, 2019 The Signal Transducer and Activator of Transcription (STAT)3 and 5 proteins are activated by many cytokine receptors to regulate specific gene expression and mitochondrial functions. Their role in cancer is largely context-dependent as they can both act as oncogenes and tumor suppressors.
Sebastian Igelmann +2 more
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Радиационная гигиена, 2017 Objective: Assessment of solid cancer incidence risk in the Chelyabinsk subcohort of the East Urals Radioactive Trace over the 53-year period of follow-up with use of the individualized doses accumulated in the soft tissues calculated on the basis of the
S. S. Silkin +3 more
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, 2022 Electrolyte disorders are a frequent finding in cancer patients. In the majority of cases the etiologies of such disorders are common to all cancer types (i.e. diuretic-induced hyponatremia or hypokalemia). Sometimes, electrolyte disorders are caused by paraneoplastic syndromes or are due to cancer therapy.
Jessica Iorio +2 more
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Study of miRNA Based Gene Regulation, Involved in Solid Cancer, by the Assistance of Argonaute Protein [PDF]
Genomics & Informatics, 2016 Solid tumor is generally observed in tissues of epithelial or endothelial cells of lung, breast, prostate, pancreases, colorectal, stomach, and bladder, where several genes transcription is regulated by the microRNAs (miRNAs).
Surya Narayan Rath +3 more
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