Results 1 to 10 of about 757,777 (265)

Targeting PD-L1 in solid cancer with myeloid cells expressing a CAR-like immune receptor [PDF]

Frontiers in Immunology
IntroductionSolid cancers Myeloid cells are prevalent in solid cancers, but they frequently exhibit an anti-inflammatory pro-tumor phenotype that contribute to the immunosuppressive tumor microenvironment (TME), which hinders the effectiveness of cancer ...
Kayla Myers Chen, Daniel Grun, Brian Gautier, Shivaprasad Venkatesha, Michael Maddox, Ai-Hong Zhang, Peter Andersen, Peter Andersen   +7 more
doaj   +2 more sources

Prevalence and impact of multidrug-resistant bacteria in solid cancer patients with bloodstream infection: a 25-year trend analysis [PDF]

Microbiology Spectrum
The study aimed to describe the epidemiology of multidrug-resistant (MDR) bacteria among solid cancer (SC) patients with bloodstream infections (BSIs), evaluating inappropriate empiric antibiotic treatment (IEAT) use and mortality trends over a 25-year ...
Carlos Lopera, Patricia Monzó, Tommaso Francesco Aiello, Mariana Chumbita, Olivier Peyrony, Antonio Gallardo-Pizarro, Cristina Pitart, Guillermo Cuervo, Laura Morata, Marta Bodro, Sabina Herrera, Ana Del Río, José Antonio Martínez, Alex Soriano, Pedro Puerta-Alcalde, Carolina Garcia-Vidal   +15 more
doaj   +2 more sources

Genome-wide mutational signatures in low-coverage whole genome sequencing of cell-free DNA

Nature Communications, 2022
Detection of mutational signatures in cell-free DNA (cfDNA) is challenging due to low sequence coverage and low mutant allele fractions. Here, the authors identify mutational signatures in plasma whole genome sequencing of cancer patients and use machine
Jonathan C. M. Wan, Dennis Stephens, Lingqi Luo, James R. White, Caitlin M. Stewart, Benoît Rousseau, Dana W. Y. Tsui, Luis A. Diaz   +7 more
doaj   +1 more source

A New Synthetic Curcuminoid Displays Antitumor Activities in Metastasized Melanoma

Cells, 2023
Aim: The semisynthetic derivatives MePip-SF5 and isogarcinol, which are aligned with the natural products curcumin and garcinol, were tested for their antitumor effects in a preclinical model of pulmonary melanoma metastasis.
Leonard Kaps, Adrian Klefenz, Henry Traenckner, Paul Schneider, Ion Andronache, Rainer Schobert, Bernhard Biersack, Detlef Schuppan   +7 more
doaj   +1 more source

No Impact of Fluconazole to Echinocandins Replacement as First-Line Therapy on the Epidemiology of Yeast Fungemia (Hospital-Driven Active Surveillance, 2004–2017, Paris, France)

Frontiers in Medicine, 2021
Replacement of fluconazole by echinocandins as the first-line therapy for yeast-related fungemia could have an impact on both the mortality rate and the epidemiology of yeast species responsible for candidemia.
Stéphane Bretagne, Stéphane Bretagne, Stéphane Bretagne, Marie Desnos-Ollivier, Karine Sitbon, Olivier Lortholary, Olivier Lortholary, Olivier Lortholary, Didier Che, Françoise Dromer, Participants of the YEASTS   +10 more
doaj   +1 more source

Wilms’ Tumor 1 (WT1): The Vaccine for Cancer [PDF]

Journal of Immunotherapy and Precision Oncology, 2020
Vaccines have been used to fight and protect against infectious diseases for centuries. With the emergence of immunotherapy in cancer treatment, researchers began investigating vaccines that could be used against cancer, especially against tumors that ...
Kyaw Zaw Hein, Shuyang Yao, Siqing Fu
doaj   +1 more source

Immunogenicity evaluation of ChAdox1 nCov-19 (AZD1222) vaccine in solid cancer patients in Chulabhorn Hospital

Human Vaccines & Immunotherapeutics, 2022
Introduction Cancer patients are more vulnerable to coronavirus disease 2019 (COVID-19) owing to their compromised immune status. However, data regarding COVID-19 vaccine safety and immune response in cancer patients are scarce.
Piyarat Limpawittayakul, Prakongboon Sungkasubun, Worawit Chaiwiriyawong, Archara Supavavej, Bowon Weerasubpong, Jomtana Siripaibun, Chumut Phanthunane, Wisut Lamlertthon, Teerapat Ungtrakul, Kriangkrai Tawinprai, Walaipan Tantiyavarong, Chayanee Samdaengpan   +11 more
doaj   +1 more source

Mu opioid receptor mRNA overexpression predicts poor prognosis among 18 common solid cancers: A pan-cancer analysis

Frontiers in Oncology, 2023
BackgroundOpioids are widely used for patients with solid tumors during surgery and for cancer pain relief. We conducted a pan-cancer genomic analysis to investigate the prognostic features of Mu opioid receptor (MOR) mRNA expression across 18 primary ...
Wei Sun, Shaohui Zhuang, Minghua Cheng, Zeting Qiu   +3 more
doaj   +1 more source

Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas

Nature Communications, 2022
Generation of TNF-α in response to chemotherapy has been associated with chemo-resistance and metastasis propagation. Here the authors show that the combination of an anti-TNF antibody and cisplatin doublet chemotherapy increases anti-tumor efficacy in ...
Paul K. Paik, Jia Luo, Ni Ai, Rachel Kim, Linda Ahn, Anup Biswas, Courtney Coker, Wanchao Ma, Phillip Wong, Darren J. Buonocore, W. Victoria Lai, Jamie E. Chaft, Swarnali Acharyya, Joan Massagué, Mark G. Kris   +14 more
doaj   +1 more source

Improved survival without increased toxicity with influenza vaccination in cancer patients treated with checkpoint inhibitors

OncoImmunology, 2021
In international guidelines, influenza vaccination is recommended to cancer patients receiving antitumor treatment. Whether this recommendation should include patients treated with the recently introduced and now widely used checkpoint inhibitors (CPIs ...
Antonios Valachis, Camilla Rosén, Anthoula Koliadi, Evangelos Digkas, Alice Gustavsson, Andreas Nearchou, Gustav J Ullenhag   +6 more
doaj   +1 more source