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Utilization of the Drug-Polymer Solid Dispersion Obtained by Ball Milling as a Taste Masking Method in the Development of Orodispersible Minitablets with Hydrocortisone in Pediatric Doses. [PDF]

open access: yesPharmaceutics
Trofimiuk M   +9 more
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Matrix solid-phase dispersion

Journal of Chromatography A, 2000
Matrix solid-phase dispersion (MSPD) is a patented process, first reported in 1989, for conducting simultaneous disruption and extraction of solid and semi-solid samples. MSPD permits complete fractionation of the sample matrix components as well as the ability to selectively elute a single compound or several classes of compounds from the same sample.
Steven A Barker
exaly   +3 more sources

Polymorphism in Solid Dispersions

Crystal Growth & Design, 2019
Solid dispersions embed active pharmaceutical ingredients in polymeric carriers to improve their solubility. Three solid dispersion preparation techniques are typically employed: solvent evaporation, solvent-fusion, and fusion methods. Although these are also widely recommended as preparative methods for phase diagram determination, few examples exist ...
Karina Sanabria Ortiz   +4 more
openaire   +2 more sources

Solid dispersion of ketoprofen in pellets

International Journal of Pharmaceutics, 2000
The formulation of ternary solid dispersions of ketoprofen with Macrogol and kollagen hydrolizate derivative as carriers was elaborated on the basis of the results of the experiments in which different methods of solid dispersion preparation (melting, solvent method, different cooling), different concentrations of drug/carriers and molecular weight of ...
R, Jachowicz   +4 more
openaire   +2 more sources

Solid dispersions of dihydroartemisinin in polyvinylpyrrolidone

Archives of Pharmacal Research, 2008
In the present study the physicochemical characteristics of dihydroartemisinin, polyvinylpyrrolidone and their solid dispersions were evaluated at various proportions of drug and polyvinylpyrrolidone. These properties were investigated with X-ray diffraction, fourier transform infrared spectrophotometry, differential scanning calorimetry, equilibrium ...
Ansari, M., Sunderland, Bruce
openaire   +3 more sources

Exciton dispersion in molecular solids

Journal of Physics: Condensed Matter, 2015
The investigation of the exciton dispersion (i.e. the exciton energy dependence as a function of the momentum carried by the electron-hole pair) is a powerful approach to identify the exciton character, ranging from the strongly localised Frenkel to the delocalised Wannier-Mott limiting cases.
Cudazzo P.   +3 more
openaire   +5 more sources

Characterization of nifedipine solid dispersions

International Journal of Pharmaceutics, 2002
The sublingual administration of nifedipine (NIF) is currently used in clinical practice. The sublingual administration of NIF solid dispersions (SD), by using a suitable dispenser, appears an interesting approach in the treatment of moderate and severe hypertensive emergencies.
F. Cilurzo   +3 more
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Evaluation of Solid Dispersions of Clofazimine

Drug Development and Industrial Pharmacy, 2002
Clofazimine (CLF) was formulated with polyethylene glycol (PEG) and polyvinyl pyrrolidone (PVP) as a solid solid dispersion (SSD) to increase the aqueous solubility and dissolution rate of the drug. Different molecular weights of PEG (1500, 4000, 6000, and 9000 Da) and PVP (14,000 and 44,000 Da) were used in different drug:carrier weight ratios (1:1, 1:
Ajit S, Narang, Anand K, Srivastava
openaire   +2 more sources

Solid-state characterization of nifedipine solid dispersions

International Journal of Pharmaceutics, 2002
The purpose of this study is to characterize the nature and solid-state properties of a solid dispersion system of nifedipine (33.3% w/w) in a polymer matrix consisting of Pluronic F68 (33.3% w/w) and Gelucire 50/13 (33.3% w/w). The nature of nifedipine dispersed in the matrix was studied by powder X-ray diffractometry (PXRD), differential scanning ...
Sudha R, Vippagunta   +3 more
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