Results 51 to 60 of about 4,306,472 (236)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Consumer Preferences and Perceptions towards the use Colored Oral Solid Dosage Forms in Baghdad [PDF]
Archives of Pharmacy Practice, 2010 Objective: The main aims of this study were to determine consumers’ preferences and perceptions in Baghdad towards the color of Oral Solid Dosage Form.Materials and Methods: A cross sectional study was conducted using a self–administered questionnaire. A
Inas Rifaat Ibrahim,*, Mohamed Izham M.I & Mahmoud Al-Haddad
doaj
Engineering Proceedings, 2022 In the present study, we aimed to evaluate the total directional hemispherical reflectance (THR) in expired and unexpired effervescent tablets. Expired tablets were stored in ambient conditions.
Beata Sarecka-Hujar +3 more
doaj +1 more source
Estudo físico-químico dos polimorfos da progesterona e estabilização da forma metaestável sobre matrizes poliméricas [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em FarmáciaA nucleação heterogênea induzida por polímeros (PIHn) é uma técnica inovadora utilizada no "screening" de polimorfos na ...
Sibaja, Andrea Mariela Araya
core
Comparing Multi-Label Classification Methods for Provisional Biopharmaceutics Class Prediction. [PDF]
, 2014 The biopharmaceutical classification system (BCS) is now well established and utilized for the development and biowaivers of immediate oral dosage forms. The prediction of BCS class can be carried out using multilabel classification.
Taravat Ghafourian +8 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Meloxicam
MoleculesThis monograph evaluates the scientific and regulatory underpinnings for bioequivalence (BE) waiver of immediate-release (IR) solid oral meloxicam formulations, as a surrogate for in vivo pharmacokinetic trials.
Aixin Guan +5 more
doaj +1 more source
Novel process analytical technological approaches of dynamic image analysis for pharmaceutical dry particulate systems [PDF]
, 2011 With the introduction of Process Analytical Technology (PAT) and Quality by Design (QbD) concepts by the Food and Drug Administration (FDA) the pharmaceutical industry is thriving towards improved process understanding.
Nalluri, Venkateshwar Rao
core +1 more source
Glargine insulin loaded lipid nanoparticles: Oral delivery of liquid and solid oral dosage forms [PDF]
, 2021 Background and aims: The oral administration of insulin has so far been precluded by gastro-intestinal enzyme degradation and poor intestinal absorption. Preliminary evidence for peptide uptake by the gut has recently been obtained, by our research group,
Colombino, Elena +18 more
core +1 more source