Results 41 to 50 of about 4,306,472 (236)

Recent Advances in Pharmaceutical Cocrystals: From Bench to Market

Frontiers in Pharmacology, 2021
The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the chemicals to understand the physicochemical properties by particle size, size
Ravi Kumar Bandaru, Smruti Rekha Rout, Gowtham Kenguva, Bapi Gorain, Nabil A. Alhakamy, Nabil A. Alhakamy, Prashant Kesharwani, Rambabu Dandela   +7 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

The production of solid dosage forms from non-degradable polymers [PDF]

, 2015
Non-degradable polymers have an important function in medicine. Solid dosage forms for longer term implantation require to be constructed from materials that will not degrade or erode over time and also offer the utmost biocompatibility and biostability.
Major, Ian, McConville, Christopher, Fuenmayor, Evert   +2 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Ayurvedic Dosage Forms: Pressing Priorities and Challenges therein with Respect to Solid and Semisolid Oral Dosage Forms

Indian Journal of Ayurveda and Integrative Medicine KLEU
Continuous improvements in elevating traditional dosage forms to increase therapeutic efficacy, to enable patient-centric approaches, and to improve patient compliance are becoming more rational with advancements in technology and an advanced vision to ...
Sakshi Badyal, Poonam Dang, Puneet Dhawan, Himanshu Shekhar Tiwari   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

3DP Printing of Oral Solid Formulations: A Systematic Review

Pharmaceutics, 2021
Three-dimensional (3D) printing is a recent technology, which gives the possibility to manufacture personalised dosage forms and it has a broad range of applications.
Chiara R. M. Brambilla, Ogochukwu Lilian Okafor-Muo, Hany Hassanin, Amr ElShaer   +3 more
doaj   +1 more source

Estudo do polimorfismo em diferentes fármacos de interesse para a indústria farmacêutica [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaÉ sabido que os sólidos farmacêuticos podem existir em mais de uma forma sólida, as quais podem exibir diferentes ...
Limberger, Ana Luiza Marin Bortoluzzi
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Justification of conditions of salicylic acid introduction into emulsion ointment base composition [PDF]

Annals of Mechnikov's Institute, 2020
Introduction. The revival of extemporaneous production requires the updating of prescriptions, the improvement of the technology of drugs, the study of stability in the process of storage in order to extend the shelf life.
Zuykina, E.V., Polovko, N. P.
doaj   +1 more source