Results 61 to 70 of about 4,306,472 (236)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Importance of Appropriate Medication Administration in Patients with Nasogastric Feeding Tube

Journal of Pharmaceutical Research, 2023
Solid dosage forms like modified release and enteric coated formulations are considered inappropriate for nasogastric feeding tube (NGFT) administration due to varying pharmacokinetics which could lead to inadequate therapeutic responses or ...
L A Pradeep Rajkumar, Sujith J Chandy, Heber Rew Bright, V J Hema Jiji, Judith Basker, K Gunaraj   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Superdisintegrants in new solid dosage forms – a review

Current Issues in Pharmacy and Medical Sciences, 2012
Despite increasing interest in controlled-release drug delivery systems, the most common tablets are intended to be swallowed whole and to disintegrate and release their medicaments rapidly in the gastrointestinal tract.
Łukasz Zimmer, Piotr Belniak, Aleksandra Szopa, Ewa Poleszak   +3 more
doaj  

Solid Dosage Forms of Nootropic Action Based on Pantogam and Succinic Acid

Конденсированные среды и межфазные границы, 2020
In recent years, research related to the search and study of the mode of action of new and used in medicine nootropic agents has been carried out at a high rate.
Denis A. Slivkin, Yulia A. Polkovnikova, Aleksey I. Slivkin, Alena S. Belenova, Svetlana N. Suslina, Anastasia A. Kashchavtseva   +5 more
doaj   +1 more source

Caracterização e estudos das propriedades no estado sólido do cloridrato de venlafaxina [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.O cloridrato de venlafaxina (VEN) é um inibidor da recaptação da serotonina e norepinefrina eficaz no ...
Bernardi, Larissa Sakis
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Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Modeling and biopharmaceutical evaluate of topical semi – solid dosage forms of fungicidal effect with terbinafine hydrochloride. [PDF]

, 2019
The Aim: to model topical semi – solid dosage forms with terbinafine hydrochloride and to evaluate their quality by carrying out the bio-pharmaceutical tests in vitro. Objectives: 1.
Mostautienė, Vilmantė
core