Results 221 to 230 of about 339,240 (298)

New Insight into Cavitation-Assisted Chemical Refining and Enzymatic Modification of Vegetable Oils and Their Impact on Physicochemical Properties of Final Products. [PDF]

open access: yesFoods
Kalenchak K   +10 more
europepmc   +1 more source

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

open access: yesAdvanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo   +16 more
wiley   +1 more source

Mathematical modeling of the frozen zone dynamics: Towards using thermal imagers in cryotherapy. [PDF]

open access: yesPLoS One
Ivakhnenko OV   +5 more
europepmc   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

open access: yesAdvanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao   +11 more
wiley   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

open access: yesAdvanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong   +21 more
wiley   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

open access: yesAdvanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li   +8 more
wiley   +1 more source

Erasable FAP Targeted Spray‐On Probe for Fluorescence‐Guided Surgery

open access: yesAdvanced Science, EarlyView.
We present the first erasable spray‐on probe for fluorescence‐guided surgery. Following topical delivery, FAP‐FLASH550 targets fibroblast activation protein–expressing stromal cells, delineating tumor margins with high tumor‐to‐background ratios. A 365 nm UV light pulse rapidly erases fluorescent signals through triazene photodegradation and subsequent
Zachary Rabinowitz   +2 more
wiley   +1 more source

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