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Solid lipid nanoparticles for hydrophilic drugs
Journal of Controlled Release, 2021Hydrophilic drugs are proficient therapeutic agents however, delivery of these drugs is a difficult task. Hence, developing an efficient drug delivery system may require a multipronged approach. Colloidal drug delivery systems such as emulsions, liposomes, nanoemulsions, polymeric nanoparticles, and niosomes are known to enhance drug entrapment ...
Yashika, Mirchandani +2 more
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Solid Lipid Nanoparticles for Drug Delivery
2023Solid lipid nanoparticles are promising carriers that allow for the delivery of poorly water-soluble drugs and have the potential to achieve sustained drug release or targeted delivery to the site of interest. Here we describe the preparation of solid lipid nanoparticles by forming a microemulsion at an elevated temperature which, upon cooling, yields ...
Wei-Chung, Luo, Xiuling, Lu
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2006
In the last decade of the last century, solid lipid nanoparticles (SLN) have been introduced to the literature as a novel carrier system for cosmetic active ingredients and pharmaceutical drugs. SLN consist of biodegradable physiological lipids or lipidic substances and stabilisers which are generally recognised as safe (GRAS) or have a regulatory ...
Anne Saupe, Thomas Rades
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In the last decade of the last century, solid lipid nanoparticles (SLN) have been introduced to the literature as a novel carrier system for cosmetic active ingredients and pharmaceutical drugs. SLN consist of biodegradable physiological lipids or lipidic substances and stabilisers which are generally recognised as safe (GRAS) or have a regulatory ...
Anne Saupe, Thomas Rades
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Drug targeting using solid lipid nanoparticles
Chemistry and Physics of Lipids, 2014The present review aims to show the features of solid lipid nanoparticles (SLNs) which are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Because of some unique features of SLNs such as their unique size dependent properties it offers possibility to develop new ...
Elham, Rostami +5 more
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Stability of Lipid Excipients in Solid Lipid Nanoparticles
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Current Drug Delivery, 2008
The first generation of solid lipid carrier systems in nanometer range, Solid Lipid Nanoparticles (SLN), was introduced as an alternative to liposomes. SLN are aqueous colloidal dispersions, the matrix of which comprises of solid biodegradable lipids.
S S, Shidhaye +4 more
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The first generation of solid lipid carrier systems in nanometer range, Solid Lipid Nanoparticles (SLN), was introduced as an alternative to liposomes. SLN are aqueous colloidal dispersions, the matrix of which comprises of solid biodegradable lipids.
S S, Shidhaye +4 more
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Solid Lipid Nanoparticles (SLN™)
2013Solid lipid nanoparticles (SLN™) are a new generation of drug delivery systems being exploited for several drugs since the nineties. These particles can be composed of different types of solid lipids, such as glycerides, waxes, and fatty acids, and stabilized by a wide range of surfactants.
Eliana B. Souto +2 more
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Current Drug Metabolism, 2020
Background: Solid Lipid Nanoparticles (SLNs) possess unique in vivo features such as high resistivity, bioavailability, and habitation at the target site. Coating nanoparticles with polymers such as chitosan greatly affects their pharmacokinetic behavior, stability, tissue uptake, and controlled drug delivery.
Nasrin Abbasi Gharibkandi +3 more
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Background: Solid Lipid Nanoparticles (SLNs) possess unique in vivo features such as high resistivity, bioavailability, and habitation at the target site. Coating nanoparticles with polymers such as chitosan greatly affects their pharmacokinetic behavior, stability, tissue uptake, and controlled drug delivery.
Nasrin Abbasi Gharibkandi +3 more
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Thymopentin in solid lipid nanoparticles
International Journal of Pharmaceutics, 1996Abstract The pentapeptide thymopentin was englobed in solid lipid nanoparticles prepared from warm microemulsions following two different methods: from O/W microemulsion by forming the more lipophilic ion-pair with hexadecylphosphate, and from W/O/W microemulsion by dissolving the pentapeptide in the aqueous internal phase.
Silvia Morel +3 more
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