Results 51 to 60 of about 180,216 (329)

The role of surface charge in the interaction of nanoparticles with model pulmonary surfactants [PDF]

, 2018
Inhaled nanoparticles traveling through the airways are able to reach the respiratory zone of the lungs. In such event, the incoming particles first enter in contact with the liquid lining the alveolar epithelium, the pulmonary surfactant.
Berret, J. -F., Mousseau, F.
core   +4 more sources

Docetaxel-loaded solid lipid nanoparticles prevent tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells

Journal of Nanobiotechnology, 2020
Background Metastasis causes the most breast cancer-related deaths in women. Here, we investigated the antitumor effect of solid lipid nanoparticles (SLN-DTX) when used in the treatment of metastatic breast tumors using 4T1-bearing BALB/c mice.
Márcia Cristina Oliveira da Rocha, P. D. da Silva, M. A. Radicchi, B. Y. G. Andrade, J. V. de Oliveira, Tom Venus, Carolin Merker, I. Estrela-Lopis, J. P. Longo, S. Báo   +9 more
semanticscholar   +1 more source

Solid Lipid Nanoparticles by Coacervation from Natural Soaps: Preliminary Studies for Oral Delivery of an Insulin Analogue

Pharmaceutics
Background/Objectives: Oral insulin continues to constitute a challenge due to its low uptake by the gut wall and degradation by gastrointestinal proteolytic enzymes. Such concerns might be surmounted by means of nanoparticle delivery.
Annalisa Bozza, Arianna Marengo, Federica Blua, Elisabetta Marini, Stefano Bagatella, Elena Ugazio, Elisabetta Muntoni, Luigi Battaglia   +7 more
doaj   +1 more source

In Vitro Evaluation of NLS-DTX Activity in Triple-Negative Breast Cancer

Molecules, 2022
Cancer is one of the most lethal diseases in the world, and the development and improvement of treatments used in cancer therapies are extremely important for a better quality of life for patients.
Karen L. R. Paiva, Marina A. Radicchi, Sônia N. Báo   +2 more
doaj   +1 more source

Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation. [PDF]

, 2013
Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects.
Bratt, Jennifer M, Franzi, Lisa M, Kenyon, Nicholas J, Lam, Kit S, Lee, Joyce, Luo, Juntao, Zeki, Amir A   +6 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Solid Lipid Nanoparticle Formulations of Docetaxel Prepared with High Melting Point Triglycerides: In Vitro and in Vivo Evaluation

Molecular Pharmaceutics, 2014
Docetaxel (DCX) is a second generation taxane. It is approved by the U.S. Food and Drug Administration for the treatment of various types of cancer, including breast, non-small cell lung, and head and neck cancers.
Y. W. Naguib, B. L. Rodriguez, XinRan Li, S. Hursting, Robert O. Williams, Z. Cui   +5 more
semanticscholar   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Biophysicochemical interaction of a clinical pulmonary surfactant with nano-alumina

, 2015
We report on the interaction of pulmonary surfactant composed of phospholipids and proteins with nanometric alumina (Al2O3) in the context of lung exposure and nanotoxicity.
Berret, J. -F., Borgne, R. Le, Mousseau, F., Seyrek, E.   +3 more
core   +4 more sources

Formulation and Evaluation of Solid Lipid Nanoparticle (SLN) Based Topical Gel of Etoricoxib.

, 2016
The objective of present investigation was to prepare & evaluate solid lipid nanoparticle (SLN) based topical gel of non- steroidal anti-inflammatory drug (NSAID) etoricoxib for the treatment of arthritis which would attenuate the gastrointestinal ...
Roohi Kesharwani, A. Sachan, Swati Singh, D. Patel   +3 more
semanticscholar   +1 more source