Results 101 to 110 of about 4,227,910 (301)

Gas-like adhesion of two-dimensional materials onto solid surfaces

open access: yesScientific Reports, 2017
The adhesion of two-dimensional (2D) materials onto other surfaces is usually considered a solid-solid mechanical contact. Here, we conduct both atomistic simulations and theoretical modeling to show that there in fact exists an energy conversion between
Zhengrong Guo   +3 more
doaj   +1 more source

DESIGN & DEVELOPMENT OF PLANAR SOLID OXIDE FUEL CELL STACK [PDF]

open access: yes, 2013
In the present work, planar anode-supported Solid Oxide Fuel Cell short-stacks have been designed, assembled, tested and characterized. The design of the stacks and its components (frame, housing, interconnect, compressive and bonded seals) required a ...
Ortigoza Villalba, Gustavo Adolfo
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

斜齿轮三维实体造型方法的比较研究

open access: yesJixie chuandong, 2008
The object of this paper is to analyze and compare the different solid modeling methods of the helical gear from the angle of computer graphics theory.According to sweep representation,boundary representation and constructive solid geometry,the solid ...
胡福文, 郭海森, 韩云鹏
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Non-Isothermal Modeling of Planar Solid Oxide Fuel Cell [PDF]

open access: yesHydrogen, Fuel Cell & Energy Storage
A Solid Oxide Fuel Cell (SOFC) with internal reformation and a parallel flow configuration is modeled. The solution domain of the model is divided into four sections: the fuel channel, air channel, bipolar plates, and the cell core (PEN), which comprises
Mohammed Farzad, Hasan Hassanzadeh
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

轴向柱塞泵缸体集成开发之参数化研究

open access: yesJixie chuandong, 2006
With the advanced three-dimensional modeling technical of UGNX software, these basic parameters of rotor in axial plunger pumps can be brought to success at one time, the main module of UGNX software could automatically establish solid modeling of rotor,
李玉龙, 刘焜, 王学军, 徐强
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

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