Results 81 to 90 of about 4,227,910 (301)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Accurate Tooth Surface Modeling and Meshing Simulation of Helical-face gear Pair with Linear Contact Cross Axis

open access: yesJixie chuandong, 2019
The accurate tooth surface modeling of the helical-face gear pair with linear contact cross axis is given. Based on the meshing theory, the mathematical model of the tooth surface of the helical-face gear with cross axis is established, and the discrete ...
Li Jingcai   +5 more
doaj  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Creativity and Solid Modeling [PDF]

open access: yes, 2013
Creativity is becoming increasingly important in architecture and industrial design. Creativity at conceptual design stage of a design process is a requirement in today's competitive job market.
Sönmez, Murat
core   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

High-resolution solid state NMR experiments for the characterization of calcium phosphate biomaterials and biominerals [PDF]

open access: yes, 2011
Calcium phosphates form a vast family of biominerals, which have attracted much attention in fields like biology, medicine, and materials science, to name a few.
Hanna, John   +55 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Comparison and Research on Fatigue Strength Analysiswith Different FE Modeling Methods

open access: yes机车电传动, 2016
In order to improve the efficiency of engineering structural strength analysis, two types of model that solid element modeland solid-shell element model were created based on ANSYS and HyperMesh software.
QU Wenhui, MI Caiying
doaj  

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