Results 91 to 100 of about 4,227,910 (301)

Household Demand for Solid Waste Disposal Options in Malaysia [PDF]

This paper estimates the economic values of household preference for enhanced solid waste disposal services in Malaysia. The contingent valuation (CV) method estimates an average additional monthly willingness-to-pay (WTP) in solid waste management ...
Pek, Chuen Khee, Othman, Jamal
core  

Mathematical modeling of tumor growth and treatment [PDF]

, 2014
Using mathematical models to simulate dynamic biological processes has a long history. Over the past couple of decades or so, quantitative approaches have also made their way into cancer research.
Chaplain, Mark A. J., Enderling, Heiko
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Research progress in data-driven constitutive modeling of composite solid propellants

AIP Advances
With the continuous advancement of technology, composite solid propellants play an increasingly widespread and crucial role in fields such as aerospace and military applications.
Bin Yuan, Hongfu Qiang, Chunguo Yue
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Fluidized bed modeling applied to the analysis of processes: review and state of the art

Journal of Materials Research and Technology, 2015
The fluidized bed is a technology that involves multiple phases, allowing for efficient contact between them, therefore it is widely used in the chemical industry, metallurgy, oil and thermal power generation.
Caterina Gonçalves Philippsen, Antônio Cezar Faria Vilela, Leandro Dalla Zen   +2 more
doaj   +1 more source

Lagrangian Solid Modeling

, 2017
The author demonstrates a stable Lagrangian solid modeling method, tracking the interactions of solid mass particles, rather than using a meshed grid. This numerical method avoids the problem of tensile instability often seen with Smooth Particle Applied
Matthew Marko
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Surface modeling in Solid Edge

, 2021
Tato bakalářská práce se zabývá modelováním pomocí ploch v programu Solid Edge. Cílem práce je vypracování průvodce plošným modelováním, který je věnován popisu uživatelského rozhraní i jednotlivým konkrétním příkazům pro modelování v modulu "Tvorba ...
Zaduban, Josef
core   +2 more sources