Results 71 to 80 of about 4,227,910 (301)
Heterogeneous Material Modeling with Distance Fields [PDF]
, 2002 We propose a universal approach to the outstanding problem of computer modeling of continuously varying distributions of material properties satisfying prescribed material quantities and rates on a finite collection of geometric features.
Shapiro, Vadim +2 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Modelling of Tirapazamine effects on solid tumour morphology [PDF]
, 2011 Bioreductive drugs are in clinical practice to exploit the resistance from tumour microenvironments especially in the hypoxic region of tumour. We pre-sented a tumour treatment model to capture the pharmacology of one of the most prominent bioreductive ...
Kazmi, Nabila +5 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Scientific DataMaterial Testing 2.0 (MT2.0) is a paradigm that advocates for the use of rich, full-field data, such as from digital image correlation and infrared thermography, for material identification.
E. M. C. Jones +7 more
doaj +1 more source
Impact of experimental conditions on material response during forming of steel in semi-solid state [PDF]
, 2010 Semi-solid forming is an effective near-net-shape forming process to produce components with complex geometry and in fewer forming steps. It benefits from the complex thixotropic behaviour of semi-solids.
CEZARD, Pierre +4 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Solid modeling -- use and implementation
, 2000 This project studies how geometric solid modeling is implemented and utilized in small and medium sized manufacturing companies. Data were collected by comparing the functional characteristics of several commercially available solid modeling packages ...
Baillargeon, Jeremy Robert +2 more
core +3 more sources
MODELING 3D CAD AND RAPID PROTOTYPING THE PRESENTER PLANETARY GEAR [PDF]
Scientific Journal of Silesian University of Technology. Series Transport, 2014 This paper presents a methodology for modeling and prototyping presentation of the planetary gear. Shown is the way of modeling hybrid transmission gear teeth. The first step is to develop a hybrid modeling the geometry of the teeth profiles.
Tadeusz MARKOWSKI +4 more
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source