Results 51 to 60 of about 1,379,495 (302)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Role of cell deformability in the two-dimensional melting of biological tissues

, 2018
The size and shape of a large variety of polymeric particles, including biological cells, star polymers, dendrimes, and microgels, depend on the applied stresses as the particles are extremely soft.
Ciamarra, Massimo Pica, Li, Yan-Wei
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

On the Formation and Accumulation of Solid Carbon Particles in High-Enthalpy Flows Mimicking Re-Entry in the Titan Atmosphere

Fluids, 2020
The problem relating to the formation of solid particles enabled by hypersonic re-entry in methane-containing atmospheres (such as that of Titan) has been tackled in the framework of a combined experimental–numerical approach implemented via a three ...
Antonio Esposito, Marcello Lappa, Gennaro Zuppardi, Christophe Allouis, Barbara Apicella, Mario Commodo, Patrizia Minutolo, Carmela Russo   +7 more
doaj   +1 more source

Kinetics of Particles Adsorption Processes Driven by Diffusion

, 1997
The kinetics of the deposition of colloidal particles onto a solid surface is analytically studied. We take into account both the diffusion of particles from the bulk as well as the geometrical aspects of the layer of adsorbed particles.
De Groot S. R., Diamant H., J. Bonet Avalos, J. M Rubí, Jin X., Mann E. K., P Wojtaszczyk, Pomeau Y.   +7 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

High temperature resistant cermet and ceramic compositions [PDF]

, 1978
Cermet compositions having high temperature oxidation resistance, high hardness and high abrasion and wear resistance, and particularly adapted for production of high temperature resistant cermet insulator bodies are presented.
Phillips, W. M.
core   +2 more sources

Compaction and dilation rate dependence of stresses in gas-fluidized beds

, 2006
A particle dynamics-based hybrid model, consisting of monodisperse spherical solid particles and volume-averaged gas hydrodynamics, is used to study traveling planar waves (one-dimensional traveling waves) of voids formed in gas-fluidized beds of narrow ...
Crowe C. T., Davidson J. F., Derksen J., Gidaspow D., I. G. Kevrekidis, Israelachvili J. N., Jackson R., Jackson R., Moon S. J., Rowe P. N., Rumpf H., S. Sundaresan, Sung Joon Moon, Wen C. Y.   +13 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source