Results 101 to 110 of about 20,095,273 (250)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Enhancement and quenching of ZnO nanowire luminescence by electron irradiation

Discover Nano
Electron microscopy is an essential tool in the fabrication and characterization of optoelectronic devices. This study systematically investigated the stability of zinc oxide nanowires under electron irradiation, focusing on spontaneous and stimulated ...
Edwin Eobaldt, Maximilian Zapf, Gesine Wolf, Sam Imani, Johannes Nicklaus, Sven Schönherr, Carsten Ronning   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Evaluation of temperature and moisture response surface on the lipase from pumpkin seeds fermentation using Aspergillus niger - doi: 10.4025/actascitechnol.v34i3.12497

Acta Scientiarum: Technology, 2012
Agro-industrial waste has shown great potential for use in solid-state fermentation due to its low cost and promoting the growth of microorganisms. This study evaluated the interaction between temperature and moisture response surface on lipase from the ...
Luciana Cristina Lins de Aquino, Cleide Mara Faria Soares, Kyzzes Barreto de Araújo, Rafaela Cristiane Andrade Santos   +3 more
doaj  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Fate of Pomeranchuk effect in ultrahigh magnetic fields

Nature Communications
The Pomeranchuk effect is a counterintuitive phenomenon where liquid helium-3 (3He) solidifies under specific pressures, not when cooled, but when heated.
Naofumi Matsuyama, So Yokomori, Toshihiro Nomura, Yuto Ishii, Hiroaki Hayashi, Hajime Ishikawa, Kazuki Matsui, Hatsumi Mori, Koichi Kindo, Yasuhiro H. Matsuda, Shusaku Imajo   +10 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Solid-state N.M.R. studies of platinum and tin compounds [PDF]

, 1986
High-resolution solid-state N.M.R. studies of dilute spins are now possible using cross-polarisation and MAS techniques. A systematic evaluation has been undertaken to determine their applicability to spin-½ metal nuclei, in particular (^195)Pt and (^119)
Reams, Patrick William, Reams, P.W
core  

Eliminating the ionic liquid from hybrid solid state electrolytes

, 2017
Solid state electrolytes can enhance Lithium-ion (Li-ion) batteries significantly due to improved cycling performance and increased safety. In the past, several solid state electrolytes have been successfully developed, such as LISICON, garnets, etc. [1]
JOOS, Bjorn, HARDY, An, VRANKEN, Thomas, VAN BAEL, Marlies, Vereecken, Philippe   +4 more
core   +1 more source