Results 61 to 70 of about 20,095,273 (250)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Tunable and parabolic piezoelectricity in hafnia under epitaxial strain

Nature Communications
Piezoelectrics are a class of functional materials that have been extensively used for application in modern electro-mechanical and mechatronics technologies.
Hao Cheng, Peijie Jiao, Jian Wang, Mingkai Qing, Yu Deng, Jun-Ming Liu, Laurent Bellaiche, Di Wu, Yurong Yang   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Direct visualization of stacking-selective self-intercalation in epitaxial Nb1+x Se2 films

Nature Communications
Two-dimensional (2D) van der Waals (vdW) materials offer rich tuning opportunities generated by different stacking configurations or by introducing intercalants into the vdW gaps.
Hongguang Wang, Jiawei Zhang, Chen Shen, Chao Yang, Kathrin Küster, Julia Deuschle, Ulrich Starke, Hongbin Zhang, Masahiko Isobe, Dennis Huang, Peter A. van Aken, Hidenori Takagi   +11 more
doaj   +1 more source

Non-diffracting multi-electron vortex beams balancing their electron–electron interactions

Nature Communications, 2017
Vortex electron beams are generated using single electrons but their low beam-density is a limitation in electron microscopy. Here the authors propose a scheme for the realization of non-diffracting electron beams by shaping wavepackets of multiple ...
Maor Mutzafi, Ido Kaminer, Gal Harari, Mordechai Segev   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Investigations on the solid state interaction between LiAlH4 and NaNH2

, 2010
10.1016/j.jssc.2010.07.014Journal of Solid State Chemistry18392040 ...
Wu, G., Guotao Wu, Yong Shen Chua, Ping Chen, Xiong, Zhitao, Chen, P., Chen, Ping, Xiong, Z., Zhitao Xiong, Chua, Yong Shen, Wu, Guotao, Chua, Y.S., 熊智涛   +12 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Single molecule magnet with an unpaired electron trapped between two lanthanide ions inside a fullerene

Nature Communications, 2017
Single molecule magnets have demonstrated promise for information storage, molecular spintronics and quantum computing, but are limited by their low operational temperatures.
Fupin Liu, Denis S. Krylov, Lukas Spree, Stanislav M. Avdoshenko, Nataliya A. Samoylova, Marco Rosenkranz, Aram Kostanyan, Thomas Greber, Anja U. B. Wolter, Bernd Büchner, Alexey A. Popov   +10 more
doaj   +1 more source