Results 71 to 80 of about 1,375,222 (316)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Eliminating the ionic liquid from hybrid solid state electrolytes

, 2017
Solid state electrolytes can enhance Lithium-ion (Li-ion) batteries significantly due to improved cycling performance and increased safety. In the past, several solid state electrolytes have been successfully developed, such as LISICON, garnets, etc. [1]
JOOS, Bjorn, HARDY, An, VRANKEN, Thomas, VAN BAEL, Marlies, Vereecken, Philippe   +4 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Single molecule magnet with an unpaired electron trapped between two lanthanide ions inside a fullerene

Nature Communications, 2017
Single molecule magnets have demonstrated promise for information storage, molecular spintronics and quantum computing, but are limited by their low operational temperatures.
Fupin Liu, Denis S. Krylov, Lukas Spree, Stanislav M. Avdoshenko, Nataliya A. Samoylova, Marco Rosenkranz, Aram Kostanyan, Thomas Greber, Anja U. B. Wolter, Bernd Büchner, Alexey A. Popov   +10 more
doaj   +1 more source

Combination of SHS and Mechanochemical Synthesis for Nanopowder Technologies

KONA Powder and Particle Journal, 2014
The combination of mechanochemical activation and self-propagating high-temperature synthesis (SHS) have widened the possibilities for both methods. For metallic systems, the investigation showed that a short-term
T. Grigorieva, M. Korchagin, N. Lyakhov
doaj   +1 more source

Solid state NMR of sulfa-drugs [PDF]

, 2001
This work has been a study of systems, mostly of sulfa-drugs, showing polymorphic behaviour. Using different means as solid state NMR, X-ray analysis, and theoretical calculations, we have seen how it is possible to understand results obtained from the ...
Portieri, Alessia, Portieri, A.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Solid state polymeric electrolytes based on poly(epichlorohydrin)

, 2015
Elastomers constituted of the homopolymer of epichlorohydrin, its copolymer with ethylene oxide and its terpolymer with ethylene oxide and allyl-glycidyl-ether were studied as polymeric electrolytes in polymer/LiClO4 systems.
Silva, GG, daFonseca, CNP, DePaoli, MA, Lemes, NHT   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

High-impedance microwave resonators with two-photon nonlinear effects

Nature Communications
Nonlinear effects play a central role in photonics as they form the foundation for most of the device functionalities such as amplification and quantum state preparation and detection.
S. Andersson, H. Havir, A. Ranni, S. Haldar, V. F. Maisi   +4 more
doaj   +1 more source