Results 101 to 110 of about 21,741,580 (297)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Food Physical Chemistry and Biophysical Chemistry [PDF]

, 2011
Food Physical Chemistry is considered to be a branch of Food Chemistry^1,2^ concerned with the study of both physical and chemical interactions in foods in terms of physical and chemical principles applied to food systems, as well as the applications of ...
I. C. Baianu, I.C. Baianu
core  

Development of a material based on hydroxyapatite and aluminosilicate zeolites with a binding agent for the formation of bioactive coatings

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов
The hardened composite material with a porous structure was obtained by mechanochemical synthesis of nanostructured hydroxyapatite synthesized by precipitation from an aqueous solution with reinforcing additives of zirconium dioxide and silicic acid ...
V.M. Skachkov, E.A. Bogdanova, S.A. Bibanaeva, A.G. Shirokova   +3 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Nitrogen-rich transition metal nitrides [PDF]

, 2013
The solid state chemistry leading to the synthesis and characterization of metal nitrides with N:M ratios >1 is summarized. Studies of these compounds represent an emerging area of research.
Hector, Andrew L., McMillan, Paul F., Salamat, Ashkan, Kroll, Peter   +3 more
core   +1 more source

Solid State Chemistry of Ionic Fluorides [PDF]

Angewandte Chemie International Edition in English, 1976
AbstractThe results of intensive pure research into the chemistry and physics of fluorides can be pieced together to give an overall picture whose discernible outlines hold promise of numerous new compounds having unusual and in some cases unique properties. Modern technology is called upon to exploit them.
openaire   +2 more sources

The effect of silicon dioxide on the structural, thermal and transport properties of an organic ionic plastic crystal (n-C4H9)4NBF4

Chimica Techno Acta
Composite solid electrolytes based on an organic ionic plastic crystal (n-C4H9)4NBF4 with highly dispersed SiO2 with specific surface area of Ss = 324±10 m2/g have been studied for the first time. By methods of X-ray diffraction and differential scanning
Ivan Stebnitskii, Yulia Mateyshina, Nikolai Uvarov   +2 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Transforming solid-state nuclear magnetic resonance towards a chemistry-ready technique

Solid-state nuclear magnetic resonance (solid-state NMR) is an essential tool for probing local structure and dynamics in complex materials, yet its uptake in the broader chemistry community has remained limited by technical and operational barriers. The
Purea, Armin, Grohe, Kristof, Gómez, Jennifer S., Kempf, James, Seoane, Felipe, Pell, Andrew J., Alvarez, Daniel Jardon, Papawassiliou, W., Massiot, Dominique, Afrough, Armin, Schantz, Staffan, Wegner, Sebastian, Kentgens, Arno P. M., Marín-Montesinos, Ildefonso, Papawassiliou, Wassilios, Rocha, João, Karlsson, Göran, Wong, Y.T.A., Coulon, R., Jeannerat, Damien, Pintacuda, Guido, Lelli, Moreno, Aspers, Ruud L. E. G., de Castro, Vanessa Mondaini, Coulon, Romain, Lucci, Massimo, Franks, W. Trent, Lambregts, Sander F. H., Mentink‐Vigier, Frédéric, Schlagnitweit, Judith, Juhl, Dennis Wilkens, Schurko, Robert W., Iuga, Dinu, Luchinat, Claudio, Mafra, Luís, Reiter, Christian, Fayon, Franck, Kentgens, A.P.M., Brath, Ulrika, Lesage, A., Biasi, F. De, Cobas, Carlos, Pinon, Arthur C., Brown, Steven P., Sardo, Mariana, Gomez, J.S., Florian, Pierre, Lambregts, S.F.H., Šoltésová, Mária, Leskes, Michal, Pintacuda, G., Engelke, Frank, Menakath, Anjali, De Biasi, Federico, Gajan, D., Cerofolini, Linda, Bachmann, Stephanie, Vosegaard, Thomas, Aspers, R.L.E.G., Frydman, Lucio, Vaz, Esther, Wong, Y. T. Angel, Gajan, David, Jardon Alvarez, Daniel, Pinon, Arthur,, Luchinat, C., Trent Franks, W., Mentink-Vigier, Frederic, Castro, Vanessa, Angel Wong, Y. T., Schantz, Staffan,, Soltesova, Mária,, Brath, Ulrika,, Karlsson, Göran,, Lelli, M., Cerofolini, L., Coulon, Raphaële, Lesage, Anne, Juhl, Dennis W.   +78 more
core   +1 more source