Results 51 to 60 of about 35,670 (298)

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Yb:tungstate waveguide lasers [PDF]

open access: yes, 2011
Lasers find a wide range of applications in many areas including photo-biology, photo-chemistry, materials processing, imaging and telecommunications. However, the practical use of such sources is often limited by the bulky nature of existing systems.
Bain, Fiona Mair
core  

Generation of Orthogonally Polarized Mode-Locked Lasers at Wavelength of 1342 nm

open access: yesIEEE Photonics Journal, 2017
A mode-locked laser with orthogonal polarization at the wavelength of 1342 nm is experimentally achieved by using the natural birefringence of the Nd:YVO4 crystal.
Hsing-Chih Liang   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Cryogenically-cooled two-micron solid-state lasers: recent results and future prospects [PDF]

open access: yes, 2009
Efficient powerful laser sources in the two-micron regime are in demand for many applications in the areas of remote-sensing, defence, medicine, and materials interactions.
Bailey, W.O.S.   +5 more
core  

Recent Progress and Development Trend of Self-Sweeping Fiber Laser

open access: yesFrontiers in Physics, 2021
Since 2011, when Kir’yanov et al. first reported a new wavelength self-sweeping ytterbium-doped fiber laser that does not rely on any tuning element but only on the dynamic induced grating generated in the gain fiber by the standing wave resonator ...
Zhenzhong Zuo   +12 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Study of millimeter wave phase shift in 40 GHz hybrid mode locked lasers [PDF]

open access: yes, 2009
An investigation into using hybrid mode-locked lasers to implement millimeter wave phase shift is presented. The phase shift is measured directly using a vector network analyzer enabling straightforward characterization of such systems.
Cryan, MJ, Khawaja, BAM
core   +1 more source

A Review of the High-Power All-Solid-State Single-Frequency Continuous-Wave Laser

open access: yesMicromachines, 2021
High-power all-solid-state single-frequency continuous-wave (CW) lasers have been applied in basic research such as atomic physics, precision measurement, radar and laser guidance, as well as defense and military fields owing to their intrinsic ...
Weina Peng   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

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