Results 91 to 100 of about 4,346,988 (199)
Target discrimination in bubbly water
, 2012 A man-made sonar that can operate in bubbly water is relevant: decades of active sonar experience built up for deep water applications are insufficient for shallow water operations required of a changed maritime security landscape.
Chua, Gim Hwa
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Experiences with a solid tungsten divertor in ASDEX Upgrade
Nuclear Materials and Energy, 2017 In 2013 a redesigned solid tungsten divertor, Div-III, was installed in ASDEX Upgrade. In two experimental campaigns more than 2700 plasma discharges with up to 10s duration, 110MJ plasma heating, and reaching a Psep/R of 10MW/m were conducted.
A. Herrmann +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2013 International audienceThe solid hydrogen target is proposed for studies of exotic nuclei beams of Spiral projects. In this paper, the simulations works in order to study mechanical behaviours of hydrogen solid at cryogenic temperature are presented.
Commeaux, Christian, Gassot, Huimin
core +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Phosphorus recovery from sorted municipal solid waste incineration ash
, 2015 Phosphorus (P) is an essential non-renewable resource and phosphorus recovery from secondary sources has been frequently discussed. In this study, a modified acidic dissolutionprecipitation method was developed for P recovery from sorted municipal solid ...
Karlfeldt Fedje, Karin, +5 more
core +1 more source
Discoidin domain receptor 1 as a potent therapeutic target in solid tumors
hLifeDespite significant discoveries in basic cancer research and improvements in treatment options and clinical outcomes, cancer remains a major public health concern worldwide.
Shaheen Bibi +4 more
doaj +1 more source