Results 101 to 110 of about 4,346,988 (199)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Characterization of municipal solid waste in the United States : 1994 update.

, 1994
"Prepared for U.S. Environmental Protection Agency, Municipal and Industrial Solid Waste Division, Office of Solid Waste.""November 15, 1994"--T.p."EPA530-R-94-042" --Cover.Includes bibliographical references.Photocopy.Mode of access ...
United States. Office of Solid Waste. Municipal and Industrial Solid Waste Division., United States. Environmental Protection Agency. Office of Solid Waste and Emergency Response.   +1 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Solid Target production for Astrophysical Reasearch: the European target laboratory partnership in ChETEC-INFRA

International audienceThe joint work of European target laboratories in the ChETEC-INFRA project is presented, to face the new experimental challenges of nuclear astrophysics. In particular, results are presented on innovative targets of 12,13C, 16O, and
Trache, Livius, Courtin, Sandrine, State, Dana, Eliana Masha, Lanzalone, Gaetano, Iancu, Decebal, Rosario Gianluca Pizzone, Maria Letizia Sergi, Alexandra Spiridon, Sparta, Roberta, Jakub Skowronski, Marco La Cognata, Giovanni Luca Guardo, Gaetano Lanzalone, Livius Trache, Nippert, Jean, Andrei, Radu-Florin, Tamás Szücs, Mereuta, Paul, Sergi, Maria Letizia, Florea, Nicoleta, Aurora Tumino, Tumino, Aurora, Antonio Caciolli, Federico Ferraro, Dana State, Pizzone, Rosario Gianluca, Ion Burducea, Heim, Felix, Decebal Iancu, Jean Nippert, Marcel Heine, Ferraro, Federico, Livio Lamia, Lamia, Livio, Skowronski, Jakub, Antonio Massara, Caciolli, Antonio, Spiridon, Alexandra, Campostrini, Matteo, Paul Mereuta, Bastin, Beyhan, Nicoleta Florea, Sandrine Courtin, Heine, Marcel, Guardo, Giovanni Luca, Beyhan Bastin, Felix Heim, Giuseppe Gabriele Rapisarda, Masha, Eliana, Denise Piatti, Rosanna Depalo, Burducea, Ion, Radu-Florin Andrei, Massara, Antonio, Matteo Campostrini, Roberta Spartà, La Cognata, Marco, Rapisarda, Giuseppe Gabriele, Piatti, Denise, Depalo, Rosanna, Szucs, Tamas, Sparta R., Spiridon A., Heine M., State D., Piatti D., Andrei R. -F., Skowronski J., Ferraro F., Masha E., Caciolli A., Depalo R., Mereuta P., Iancu D., Heim F., Florea N., Tumino A., La Cognata M., Guardo G. L., Bastin B., Courtin S., Pizzone R. G., Nippert J., Massara A., Lanzalone G., Trache L., Burducea I., Rapisarda G. G., Sergi M. L., Campostrini M., Szucs T., Lamia L.   +92 more
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

All-solid-state lithium secondary battery and production method for all-solid-state lithium secondary battery

, 2021
An all-solid-state lithium secondary battery (1) comprising: an oxide solid electrolyte layer (11) including oxide solid electrolyte particles (11a) having lithium ion conductivity; a positive electrode active material layer (13) arranged on one surface ...
Jiaxiang Piao (13434111), Hiroyuki Ueda (13073949), Hajime Sato (76981)   +2 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Protein arginine methyltransferase 5 as a novel therapeutic target in solid tumors

Genes and Diseases
Protein arginine methyltransferase 5 (PRMT5) is the primary type II methyltransferase that mainly catalyzes symmetric demethylation of arginine residues in both histone and nonhistone proteins.
Ping Song, Fan Yang
doaj   +1 more source