Results 81 to 90 of about 4,346,988 (199)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Solid-Liquid Equilibria Modelling for triacylglycerols exhibiting multiple solid phases [PDF]

, 2009
Important end-use properties of vegetable oils based edible products are strong related to the equilibrium between a solid crystalline network and a liquid phase.
Teles dos Santos, Moises, Carrillo Le Roux, Galo, Gerbaud, Vincent   +2 more
core  

Beam characteristics of an injection-seeded solid-target plasma soft x-ray laser

, 2010
We have measured the near-field and far-field profiles (for lambda=13.9 nm) as well as temporal coherence (for lambda=18.9 nm) of injection-seeded and self-seeded solid-target amplifiers. The measurements were compared with model simulations.
Luther, B. M., Domingue, S. R., J.J. Rocca, Meng, L., S. R. Domingue, Guilbaud, O., B. M. Luther, Martz, Dale,, O. Guilbaud, Alessi, D., L. Meng, D. Alessi, Berrill, M., Klisnick, A., D. Martz, Y. Wang, Wang, Y., Rocca, J. J., M. Berrill, A. Klisnick   +19 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Targeting solid tumors with TCR-T cells: mechanisms, progress, and challenges

Frontiers in Oncology
T-cell receptor-engineered T-cell (TCR-T) therapy has emerged as a promising strategy for solid tumors because it enables recognition of intracellular antigens presented by human leukocyte antigen (HLA) molecules, thereby extending targetability beyond ...
Wenfang Hu, Zhongyu Zhang, Mengyao Pan, Weiye Wang, Zibing Wang   +4 more
doaj   +1 more source

Improved Sensitivity for Solid-Support Invasive Cleavage Reactions with Flow Cytometry Analysis

BioTechniques, 2003
A new configuration of the solid-support invasive cleavage reaction provides a small reaction-volume format for high-sensitivity discrimination of nucleic acid targets with single nucleotide differences. With target concentrations as low as 2 amol/assay,
P. Wilkins Stevens, K.V.N. Rao, J.G. Hall, V. Lyamichev, B.P. Neri, D.M. Kelso   +5 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Production Process of 89Zr Based on C30 Cyclotron

Yuanzineng kexue jishu
Due to the good decay modes and suitable half-life, 89Zr is widely used in the field of immune-PET imaging. The objective is to develop a new target system suitable for cyclotron nuclide production and to obtain a new method for batch production of 89Zr.
WEN Kai1,2,3,  DUAN Fei1,2,3,  LI Guang1,2,3,  MA Chengwei1,2,3,  WANG Xiaoming1,2,3,  ZHAO Ziyu1,2,3,  CHU Haomiao1,2,3,  LI Chao1,2,3,  WANG Chengzhi1,2,3,  WANG Chunlin1,2,3
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source