Results 51 to 60 of about 649,583 (215)

Bystander effects of ionizing radiation: conditioned media from X-ray irradiated MCF-7 cells increases the angiogenic ability of endothelial cells

Cell Communication and Signaling, 2019
Background Non-targeting effects of radiotherapy have become as clinical concern due to secondary tumorigenesis in the patients receiving radiotherapy.
Nasrollah Jabbari, Muhammad Nawaz, Jafar Rezaie   +2 more
doaj   +1 more source

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques, Mariana dos Santos Murra, Welinton Hirai, Ana Laura Balduino do Nascimento, Karla Emilia de Sá Rodrigues, Wilson Elias de Oliveira Junior   +5 more
wiley   +1 more source

Targeting HER2 in metastatic urothelial carcinoma: a contemporary review

Oncologie
Metastatic urothelial carcinoma (mUC) is considered an incurable malignancy; however, patient outcomes are improving with the adoption of novel treatments.
Jang Albert, Ghimirey Nirmala, Kumar Hamsa L.S., Mendiratta Prateek, Rao Santosh, Sheng Iris Y., Barata Pedro C., Garcia Jorge A., Brown Jason R.   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Molecular Characterization of Advanced-Stage Melanomas in Clinical Practice Using a Laboratory-Developed Next-Generation Sequencing Panel

Diagnostics
Cutaneous melanoma is one of the most lethal tumors among skin cancers, characterized by complex genetic and molecular alterations that result in uncontrolled cell proliferation and metastatic spread.
Thais Maloberti, Antonio De Leo, Sara Coluccelli, Viviana Sanza, Elisa Gruppioni, Annalisa Altimari, Francesca Comito, Barbara Melotti, Paola Valeria Marchese, Emi Dika, Federico Venturi, Barbara Corti, Giulia Ciccimarra, Crina Adriana Ciceu, Giovanni Tallini, Dario de Biase   +15 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Liquid clues: tracking early-stage breast cancer with ctDNA - a mini review

Frontiers in Oncology
Circulating tumor DNA (ctDNA) is a testing modality that has several potential applications in the management of non-metastatic breast cancer. In this mini review, we discuss its role in early detection, treatment response assessment, and surveillance ...
Saumya Easaw, Johann Hsu, Nury Steuerwald, Arielle L. Heeke   +3 more
doaj   +1 more source

Targeting EGFR in Esophagogastric Cancer

Frontiers in Oncology, 2020
Esophagogastric cancer (EGC) remains a major cause of cancer-related mortality. Overall survival in the metastatic setting remains poor, with few molecular targeted approaches having been successfully incorporated into routine care to-date: only first ...
Steven B. Maron, James Xu, Yelena Y. Janjigian   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Potential therapeutic drug candidates against SARS-CoV-2 (COVID‐19) through molecular docking: A review [PDF]

Health Science Monitor, 2022
The severe acute respiratory syndrome coronavirus 2 (known as COVID-19), initially appeared in the Wuhan city of China in December 2019, has become a current medical issue around the world.
Aynaz Nourani, Vahid Rahimkhoei, Ali Akbari   +2 more
doaj