Results 191 to 200 of about 2,494,673 (310)

Biphasic Co‐Delivery of Curcumin and 5‐FU using 3D‐Printed Dissolving Microneedles for Skin Cancer Therapy

Advanced Healthcare Materials, EarlyView.
Using pixel‐aware digital light processing, the authors created high‐resolution, dissolvable microneedles from a PEGDA/VP matrix. These microneedles encapsulate curcumin and 5‐fluorouracil and dissolve in the skin, co‐delivering drugs directly to tumours.
Rutuja N. Meshram, Dimitrios A. Lamprou
wiley   +1 more source

Targeting CD24 Activates Macrophages to Reduce Tumor Burden in Preclinical Models of Solid Tumors. [PDF]

Clin Cancer Res
Faget DV, Brewer RE, Sampaio J, Blacker G, Forcina GC, Qazi S, Malusare PR, Ludwig S, Hart KE, Hansen JM, Beans A, Virani R, Dorigo O, Rousseau R, Ko PJ, Cao JY, Burg JS, Majeti R, Weissman IL, Barkal AA, Maute RL, Kahn SA.   +21 more
europepmc   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Combination of CIK cells with oncolytic viruses: A potential Immunovirotherapy strategy for the treatment of solid tumors. [PDF]

Transl Oncol
Parvinzad Leilan M, Arianejad M, Omidi Sarajar B, Tavoosidana G.   +3 more
europepmc   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Beyond KIR and NKG2A blockade: reprogramming NK-cell immunity in solid tumors. [PDF]

Front Cell Dev Biol
Pastorino C, Falco M, Giordano C, Zarefeizabadi N, Rutigliani M, Carbone A, Clavarezza M, Ortolani F, Nanni L, Della Chiesa M, Sivori S, Carlomagno S.   +11 more
europepmc   +1 more source

Silicone Breast Implants as a Model System for Understanding Polymer Permeation in Soft Materials In Vivo

Advanced Healthcare Materials, EarlyView.
Silicone breast implants are presented as a model system for understanding polymer permeation in vivo. Rather than representing material failure, “gel bleed” emerges from solution–diffusion transport‐mediated. By integrating polymer architecture, physicochemical transport, and biointerfacial processes, this review provides a unified framework that ...
D. Bouyer, H. Mutlu, C. Charmette, E. Randrianaridera, Z. Adaidi, R. Hedna, L. Pieuchot, I. Pluvy, K. Anselme, N. Couturier, J. P. Mericq, A. Ponche, I. Brigaud   +12 more
wiley   +1 more source

Comprehensive Genomic and Transcriptomic Characterization of MTAP Loss across Advanced Solid Tumors. [PDF]

Clin Cancer Res
Seguchi K, Fujisawa T, Ikeda S, Oyama Y, Nonomura N, Morizane C, Iwata H, Okano S, Watari H, Namikawa K, Kadowaki S, Ueno M, Oki E, Boku S, Yuki S, Yamagami W, Nishina T, Kudo T, Takahashi N, Bando H, Yoshino T, Nakamura Y.   +21 more
europepmc   +1 more source

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source

Trastuzumab Deruxtecan-Associated Pneumonitis in Non-Breast Solid Tumors: A Retrospective Cohort Study. [PDF]

J Immunother Precis Oncol
Attia AM, Delgado JCT, Lecaros Zavalla AD, Medina KB, Flores Hernandez IA, Villarreal EJ, Faiz SA, Shroff GS, Meric-Bernstam F, Lim B, Altan M, Sheshadri A.   +11 more
europepmc   +1 more source