Results 161 to 170 of about 2,494,673 (310)

Population pharmacokinetics for the CTLA-4 modulator gotistobart in patients with advanced solid tumors. [PDF]

J Clin Pharmacol
Li T, Xue J, Liu Y, Yang J, Weiss ID, Kharma HA, Su J, Shen Y, Yang T, Madrasi K, Engler F, Liang S, Zheng P.   +12 more
europepmc   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Peptide Therapeutics for Solid Tumors: Functional Classes, AI-Enhanced Discovery and Clinical Advances. [PDF]

J Pept Sci
Liang J, Tang X, Li H, Fang Y, Jiang F.
europepmc   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

Pineal Region Tumors : Diagnosis and Treatment Options /

, 2009
The pineal region is an anatomic location where various intracranial tumors, in particular germ cell tumors and pineal parenchymal tumors, occur. Interestingly, pineal germ cell tumors are detected more frequently in Asian countries, including Japan ...
Kobayashi, T.
core  

A new perspective on immune evasion: escaping immune surveillance by inactivating tumor suppressors

Signal Transduction and Targeted Therapy, 2022
Svenja Mergener, Samuel Peña-Llopis
doaj   +1 more source

Utility of Ultra-Low-Pass Whole Genome Sequencing in Bile CfDNA for the Management of Patients With Biliary Strictures

The Journal of Liquid Biopsy, 2023
M. Arechederra, C. Rojo, M. Rullán, M. Elizalde, J. Herranz, D. Oyón, J. Argemí, J. Urman, M. Ávila, C. Berasain   +9 more
doaj   +1 more source

A review on toxicities of T-cell engager-based therapies in solid tumors. [PDF]

Ther Adv Med Oncol
Bastien E, Vacheret C, Sanchez R, Lucibello F, Girard N, Romano E.   +5 more
europepmc   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Mechanical properties of the tumor microenvironment: drivers of immunotherapy resistance in solid tumors. [PDF]

Front Immunol
Zhang Z, Deng T, Zhou W, Tan X.
europepmc   +1 more source