Results 61 to 70 of about 8,266,387 (310)

MYC targeting by OMO-103 in solid tumors: a phase 1 trial

Nature Medicine
Among the ‘most wanted’ targets in cancer therapy is the oncogene MYC, which coordinates key transcriptional programs in tumor development and maintenance. It has, however, long been considered undruggable.
E. Garralda, M. Beaulieu, Víctor Moreno, S. Casacuberta-Serra, S. Martínez-Martín, L. Foradada, G. Alonso, D. Massó-Vallés, S. López-Estévez, T. Jauset, E. Corral de la Fuente, B. Doger, T. Hernández, R. Pérez-López, O. Arqués, Virginia Castillo Cano, J. Morales, J. Whitfield, Manuela Niewel, L. Soucek, Emiliano Calvo   +20 more
semanticscholar   +1 more source

Angiogenesis as a hallmark of solid tumors - clinical perspectives

Cellular Oncology, 2021
Angiogenesis is a key and early step in tumorigenesis, and is known as a hallmark of solid tumors and a key promoter of tumor recurrence. Unlike normal tissue vessels, the architecture of the tumor vasculature is abnormal, being leaky, tortuous, fragile ...
Jamal Majidpoor, K. Mortezaee
semanticscholar   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Co-targeting of epigenetic regulators and BCL-XL improves efficacy of immune checkpoint blockade therapy in multiple solid tumors

Molecular Cancer
Summary Epigenetic modulators in combination with proapoptotic drugs have become the standard of care treatment in hematological malignancies. Conversely, these combinations have failed to demonstrate clinical efficacy in solid tumors.
Yaiza Senent, Vicente Fresquet, Victoria Jiménez, Karmele Valencia, Francisco Exposito, Patxi San Martín-Úriz, Gracián Camps, Eva Fernández-Pierola, Borja Ruiz-Fernández de Córdoba, Marisol González-Huarriz, Ibon Tamayo, Ana Remírez, Haritz Moreno, Diego Serrano, Daniel Ajona, Marta M. Alonso, Fernando Lecanda, Antonio Pineda-Lucena, Felipe Prósper, Miguel F. Sanmamed, Alfonso Calvo, Jose A. Martinez-Climent, Ruben Pio   +22 more
doaj   +1 more source

Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors

bioRxiv, 2021
Adoptive cell therapy (ACT) has proven to be highly effective in treating blood cancers such as B cell malignancies, but traditional approaches to ACT are poorly effective in treating the multifarious solid tumors observed clinically.
Abigail K. Grosskopf, Louai Labanieh, D. Klysz, Gillie A. Roth, Peng Xu, Omokolade Adebowale, Emily C. Gale, C. Jons, J. Klich, Jerry Yan, Caitlin L. Maikawa, Santiago Correa, Ben S. Ou, Andrea I. d’Aquino, J. Cochran, O. Chaudhuri, C. Mackall, E. Appel   +17 more
semanticscholar   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

The effect of the histological properties of tumors on transfection efficiency of electrically assisted gene delivery to solid tumors in mice

, 2007
Uniform DNA distribution in tumors is a prerequisite step for high transfection efficiency in solid tumors. To improve the transfection efficiency of electrically assisted gene delivery to solid tumors in vivo, we explored how tumor histological ...
Grosel, A., Mesojednik, S., Pavlin, D., Cemazar, M., Kranjc, S., Sersa, G., Coer, A., Tevz, G.   +7 more
core   +1 more source

Succinate dehydrogenase (SDH)-deficient renal carcinoma:a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients [PDF]

, 2014
Succinate dehydrogenase (SDH)-deficient renal carcinoma has been accepted as a provisional entity in the 2013 International Society of Urological Pathology Vancouver Classification.
Sedivcová, Monika, Yu, Darryl, Papathomas, Thomas, Niemeijer, Nicolasine D., Przybycin, Christopher, Nicoll, Katherine D, Paik, Julie, Miettinen, Markku, Yong, Jim L., Kedziora, Andrew, Andresen, Per Arne, Hes, Ondrej, Toon, Christopher W., Robinson, Bruce G, Corssmit, Eleonora P M, Michal, Michal, Chou, Angela, Hills, Kirsten, Nicoll, Katherine D., Clarkson, Adele, Clifton-bligh, Roderick J., Yong, Jim L, Maclean, Fiona, Yilmaz, Asli, Vlatkovic, Ljiljana, Niemeijer, Nicolasine D, Hartmann, Arndt, Sibony, Mathilde, Agaimy, Abbas, McKenney, Jesse K, Robinson, Bruce G., Van Leenders, Geert J.l.h., Chow, Chung W., Sioson, Loretta, Mckenney, Jesse K., Corssmit, Eleonora P.m., Tan, Puay Hoon, van Leenders, Geert J L H, Yakirevich, Evgeny, Trpkov, Kiril, Benn, Diana E., Gill, Anthony J., Chow, Chung W, Watson, Nicole, Fleming, Stewart, Magi-Galluzzi, Cristina, Clifton-Bligh, Roderick J   +46 more
core   +1 more source

Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer

Signal Transduction and Targeted Therapy
The ATP-hydrolytic ectoenzyme ENPP1 has been implicated in the metastasis and recurrence in triple-negative breast cancer (TNBC), primarily by contributing to tumor cell survival and treatment resistance.
Borja Ruiz-Fernández de Córdoba, Karmele Valencia, Connor Welch, Haritz Moreno, Susana Martínez-Canarias, Carolina Zandueta, Eduardo Gómez, Alfonso Calvo, Nerea Otegui, Mirari Echepare, Ignacio Garzón, Daniel Ajona, David Lara-Astiaso, Elisabeth Guruceaga, Laura Guembe, Rubén Pío, Ignacio Melero, Silve Vicent, Fernando Pastor, Rafael Martínez-Monge, Fernando Lecanda   +20 more
doaj   +1 more source

Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors

Cancer Cell International
The application of chimeric antigen receptor (CAR) T cells in the management of hematological malignancies has emerged as a noteworthy therapeutic breakthrough.
Tong Chen, Mingzhao Wang, Yanchao Chen, Yu-Tao Liu   +3 more
semanticscholar   +1 more source